Influence of Hypertonic Saline Solution Infusion on Defibrillation Efficacy

¹ From the University of Georgia College of Pharmacy, Augusta VA Medical Center, and Medical College of Georgia School of Medicine, Augusta; and University of Cincinnati Medical Center College College of Pharmacy
² From the University of Georgia College of Pharmacy, Augusta VA Medical Center, and Medical College of Georgia School of Medicine, Augusta
³ From the University of Cincinnati Medical Center College College of Pharmacy
⁴ From the University of Cincinnati Medical Center College College of Medicine

Hypertonic saline solution may enhance cardiac conduction via the fast inward sodium channel and alter transmembrane Ca⁺⁺ conductance via the sodium-calcium exchanger. Evidence suggests that both Ca⁺⁺ conductance and myocardial conduction velocity may affect ventricular defibrillation. Since hypertonic saline solution solutions (ie, sodium bicarbonate) may be administered to patients who have conditions that often require ventricular defibrillation (ie, cardiac arrest or hypovolemic shock), we studied the effect of hypertonic saline solution on the defibrillation threshold (DFT) in 16 pentobarbital-anesthetized domestic farm swine (20 to 30 kg). Defibrillation was performed using two interfaced epicardial electrode patches. DFTs were determined at baseline and during treatment phase. Pigs were randomly assigned to treatment consisting of either hypertonic saline solution (6 mmol/kg load, 2.0 to 3.0 mmol/kg infusion) to maintain serum sodium concentrations 10 to 15 mmol/L above baseline or control (D5W given in equal volume). DFT values (joules) that predicted 50% success were modeled from a best-fit histogram. Hypertonic saline solution did not change DFT values from baseline values (10.2±4.3 vs 10.8±7.0, respectively). Likewise, placebo (D5W) did not change DFT values from baseline values (10.1±4.5 vs 11.3±4.3). During treatment phase, DFT values were 99±28% of baseline values in the hypertonic saline solution group and 116±23% of baseline values in the D5W groups (p=0.21). The administration of hypertonic saline solution also did not affect ventricular conduction velocity, right ventricular action potential duration, or right ventricular effective refractory period. These data indicate that hypertonic saline solution does not appreciably affect defibrillation efficacy or electrical treatment of ventricular fibrillation.

Key Words: cardiac electrophysiology • hypertonic saline solution • ion conductance • ventricular defibrillation • ventricular fibrillation

Submitted on November 13, 1995
Accepted on April 2, 1996

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