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(Chest. 1996;110:823-824.)
© 1996 American College of Chest Physicians

Isolated Late Asthmatic Reaction After Exposure to a High-Molecular-Weight Occupational Agent, Subtilisin

Catherine Lemière MD1; André Cartier MD1; Jerry Dolovich MD1; and Jean-Luc Malo MD1

1 From the Department of Chest Medicine, Sacré-Coeur Hospital, Montreal, Canada

High-molecular-weight agents generally induce immediate asthmatic reactions. We report the case of a subject who experienced a reaction that started after the first hour following exposure to subtilisin, a high-molecular-weight occupational agent. Any occurrence of immediate reaction was ruled out by measuring both FEV1 and lung volumes every 10 min in the first hour. This reaction was IgE-mediated as shown by immediate skin reactivity and increased specific IgE levels.

Key Words: asthma • occupational lung disease

Submitted on March 13, 1996
Accepted on April 9, 2007






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Copyright © 1996 by the American College of Chest Physicians.