| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the Pulmonary Disease and Critical Care Medicine Unit, University of Vermont College of Medicine, Burlington
2 From the Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver
3 From the Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Seattle; and the Colorado Altitude Research Institute, Keystone
Study objectives: Inflammation may contribute to the pathogenesis of high-altitude pulmonary edema (HAPE). This study was designed to determine whether a marker of inflammation, urinary leukotriene E4 (LTE4), is elevated in patients with HAPE.
Design: We conducted a case-control study to collect clinical data and urine samples from HAPE patients and healthy control subjects at moderate altitude (
2727 m), and follow-up urine samples from HAPE patients following their return to low altitude (
1,600 m).
Setting: Five medical clinics in Summit County, Colorado.
Patients: Questionnaire data were evaluated in 71 HAPE patients and 36 control subjects. Urinary LTE4 levels were determined from a random subset of 38 HAPE patients and 10 control subjects presenting at moderate altitude, and on 5 HAPE patients who had returned to low altitude.
Measurements and results: Using an enzyme immunoassay technique, urinary LTE4 levels were found to be significantly higher in HAPE patients (123 [16 to 468] pg/mg creatinine, geometric mean [range]) than in control subjects (69 [38 to 135]), p=0.02. Following return to low altitude, urinary LTE4 levels fell significantly from 122 (41.8 to 309) to 53.6 (27.6 to 104) pg/mg creatinine (p=0.05). Urinary LTE4 levels were not related to age, sex, time at altitude, physical condition or habitual exercise, recent use of alcohol or nonsteroidal anti-inflammatory drugs (NSAIDs), or oxygen saturation. Clinical factors associated with HAPE included male sex, regular exercise, and recent use of NSAIDs.
Conclusions: We conclude that urinary LTE4 levels are elevated in patients with HAPE, supporting the view that HAPE involves inflammatory mechanisms.
Key Words: high altitude • inflammation • leukotrienes • nonsteroidal anti-inflammatory drugs • pulmonary edema
Submitted on January 25, 1996
Accepted on April 30, 2007
This article has been cited by other articles:
|
|
 |
|
  C. K. Grissom, L. D. Richer, and M. R. Elstad The Effects of a 5-Lipoxygenase Inhibitor on Acute Mountain Sickness and Urinary Leukotriene E4 After Ascent to High Altitude Chest, February 1, 2005; 127(2): 565 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Raymond Altitude Pulmonary Edema Below 8,000 Feet: What Are We Missing? Chest, January 1, 2003; 123(1): 5 - 7. [Full Text] [PDF]
|
|
|
|
|
|
A. L. Gabry, X. Ledoux, M. Mozziconacci, and C. Martin High-Altitude Pulmonary Edema at Moderate Altitude (< 2,400 m; 7,870 feet): A Series of 52 Patients Chest, January 1, 2003; 123(1): 49 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Swenson, M. Maggiorini, S. Mongovin, J. S. R. Gibbs, I. Greve, H. Mairbaurl, and P. Bartsch Pathogenesis of High-Altitude Pulmonary Edema: Inflammation Is Not an Etiologic Factor JAMA, May 1, 2002; 287(17): 2228 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hackett and D. Rennie High-Altitude Pulmonary Edema JAMA, May 1, 2002; 287(17): 2275 - 2278. [Full Text] [PDF]
|
|
|
|
|
|
J. B. Slade Jr, T. Hattori, C. S. Ray, A. A. Bove, and P. Cianci Pulmonary Edema Associated With Scuba Diving : Case Reports and Review Chest, November 1, 2001; 120(5): 1686 - 1694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Maloney, D. Wang, T. Duncan, N. Voelkel, and S. Ruoss Plasma Vascular Endothelial Growth Factor in Acute Mountain Sickness Chest, July 1, 2000; 118(1): 47 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. DUPLAIN, C. SARTORI, M. LEPORI, M. EGLI, Y. ALLEMANN, P. NICOD, and U. SCHERRER Exhaled Nitric Oxide in High-Altitude Pulmonary Edema . Role in the Regulation of Pulmonary Vascular Tone and Evidence for a Role against Inflammation Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 221 - 224. [Abstract] [Full Text]
|
|
|
|
|
|
P. Bartsch, U. Eichenberger, P. E. Ballmer, J. S. R. Gibbs, C. Schirlo, O. Oelz, and E. Mayatepek Urinary Leukotriene E4 Levels Are Not Increased Prior to High-Altitude Pulmonary Edema Chest, May 1, 2000; 117(5): 1393 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kishioka, M. P. Dorighi, and B. K. Rubin Perfluorooctyl Bromide (Perflubron) Stimulates Mucin Secretion in the Ferret Trachea Chest, March 1, 1999; 115(3): 823 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Carpenter, J. T. Reeves, and A. G. Durmowicz Viral respiratory infection increases susceptibility of young rats to hypoxia-induced pulmonary edema J Appl Physiol, March 1, 1998; 84(3): 1048 - 1054. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
