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(Chest. 1996;110:1243-1247.)
© 1996 American College of Chest Physicians

Assessment of Right Ventricle Function and Pulmonary Artery Circulation by Cine-MRI in Patients With AIDS

Enrique Casalino MD1; Jean-Pierre Laissy MD, PhD2; Philippe Soyer MD2; Elisabeth Bouvet MD, PhD1; and François Vachon MD1

1 From the Infectious Disease Intensive Care Unit, Bichat-Claude Bernard University Hospital, Paris, France
2 From the Department of Radiology, Bichat-Claude Bernard University Hospital, Paris, France

Objective: To evaluate right ventricle (RV) anatomy and performance and its relationships with pulmonary circulation in AIDS patients.

Design: We conducted a prospective blinded study by using cine-MRI, a well-accepted method to assess RV and pulmonary circulation.

Setting: A university hospital.

Participants: Ten healthy volunteers and 13 asymptomatic AIDS patients.

Measurements: RV end-diastolic and end-systolic volumes, RV ejection fraction (RVEF), pulmonary artery (PA) diameter, main pulmonary artery distensibility (MPAD), RV free wall diastolic thickness (RVWT), and RV mass were measured. The RVWT/left ventricular wall thickness index was calculated.

Results: AIDS patients had significantly increased RV end-diastolic and end-systolic volumes and decreased RVEF (50±10 vs 59±6; p<0.03). Four AIDS patients had RV wall motion abnormalities; 5 (38%) had an RVEF under 45%. RVWT, the RVWT/left ventricular wall thickness index, and PA diameter were significantly increased in AIDS patients. RV mass was increased in 54% of AIDS patients. MPAD was significantly lower in AIDS patients (18.8±15 vs 26±4; p<0.01). A significant relationship was found between RV mass and MPAD (r=0.76; p=0.02).

Conclusion: RV function is frequently impaired in AIDS patients. Anatomic and functional abnormalities found in RV and PA parameters suggest a systolic overload on RV. Pulmonary circulation abnormalities may influence RV structure and function in AIDS patients.

Key Words: AIDS (acquired immunodeficiency syndrome) • cardiac • circulation • pulmonary • HIV (human immunodeficiency virus) • magnetic resonance imaging • right ventricle • function

Submitted on February 14, 1996
Accepted on July 29, 2007




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