Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brubacher, J. R.
Right arrow Articles by Hoffman, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brubacher, J. R.
Right arrow Articles by Hoffman, R. S.
(Chest. 1996;110:1282-1288.)
© 1996 American College of Chest Physicians

Treatment of Toad Venom Poisoning With Digoxin-Specific Fab Fragments

Jeffrey R. Brubacher MD1; Michael B. Heller PhD2; Padinjarekuttu R. Ravikumar PhD3; Theodore Bania MD1; and Robert S. Hoffman MD4

1 From the New York City Poison Control Center, New York City Department of Health, New York
2 From the Bureau of Laboratories, and the Environmental Sciences Division, New York City Department of Health, New York
3 From the Bureau of Laboratories, New York City Department of Health, New York
4 From the New York City Poison Control Center, New York City Department of Health; and the Department of Emergency Medicine, Bellevue Hospital Center, New York

Toxicity from toad venom poisoning is similar to digoxin toxicity and carries a high mortality rate. We report on six previously healthy men who developed vomiting and bradycardia after ingesting a purported topical aphrodisiac. Each patient had positive apparent digoxin levels and the first four patients died of cardiac dysrhythmias. The last two patients recovered following treatment with digoxin Fab fragments. We analyzed samples of the purported aphrodisiac and found that it was identical to Chan Su, a Chinese medication made from toad venom. To our knowledge, this is the first reported use of digoxin Fab fragments to treat toad venom poisoning.

Key Words: bufodienolides • cardenolides • cardiac glycosides • digoxin • digoxin Fab fragments • toad venom

Submitted on March 21, 1996
Accepted on May 20, 2007




This article has been cited by other articles:


Home page
 Journal of Pharmacy PracticeHome page
M. R. Litonjua, S. Penton, C. Robinson, and G. P. Daubert
Digoxin: The Monarch of Cardiac Toxicities
Journal of Pharmacy Practice, June 1, 2005; 18(3): 157 - 168.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Pullen, D. P Brooks, and R. M. Edwards
Characterization of the Neutralizing Activity of Digoxin-Specific Fab toward Ouabain-Like Steroids
J. Pharmacol. Exp. Ther., July 1, 2004; 310(1): 319 - 325.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R M Gowda, R A Cohen, and I A Khan
Toad venom poisoning: resemblance to digoxin toxicity and therapeutic implications
Heart, April 1, 2003; 89(4): e14 - 14.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
M. Eddleston and D.A. Warrell
Management of acute yellow oleander poisoning
QJM, September 1, 1999; 92(9): 483 - 485.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
W. J. Ball Jr., R. Kasturi, P. Dey, M. Tabet, S. O'Donnell, D. Hudson, and D. Fishwild
Isolation and Characterization of Human Monoclonal Antibodies to Digoxin
J. Immunol., August 15, 1999; 163(4): 2291 - 2298.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American College of Chest Physicians.