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(Chest. 1996;110:248S-250S.)
© 1996 American College of Chest Physicians

Pathogenesis of Hereditary Emphysema and Replacement Therapy for agr1-Antitrypsin Deficiency

Insight Into the More Common Forms of Emphysema

James E. Gadek MD, FCCP1 and Eric R. Pacht MD1

1 From the Department of Internal Medicine, Ohio State University, Columbus

The pathogenesis of emphysema and agr1-antitrypsin deficiency are explored and the mechanisms of disease in agr1-antitrypsin deficiency are then applied to more common forms of COPD, mainly cigarette smoke-induced emphysema.

Key Words: agr1-antitrypsin • antioxidant • antiprotease • cigarette smoking • emphysema • neutrophil elastase • oxidant • protease






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Copyright © 1996 by the American College of Chest Physicians.