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(Chest. 1997;111:110-114.)
© 1997 American College of Chest Physicians

Morphometric Evaluation of Argyrophilic Nucleolar Organizer Region Is Useful in Predicting Long-term Survival in Squamous Cell Carcinoma of the Lung

Leila Antonangelo MD, PhD1; Fabiola Del Carlo Bernardi MD1; Vera Luiza Capelozzi MD, PhD1; Tereza Yae Takagaki MD, PhD2; Riad Naim Younes MD3; Neide Yagi BSc1; and Paulo Hilário Nascimento Saldiva MD, PhD, FCCP1

1 From the Laboratory of Experimental Air Pollution, Department of Pathology, University of São Paulo, Brazil
2 From Discipline of Pneumology, Faculty of Medicine, University of São Paulo, Brazil
3 From the Department of Thoracic Surgery, Hospital A.C. Camargo, São Paulo, Brazil

Nucleolar organizer regions identified by means of an argyrophilic technique (AgNOR) were quantified by digital image analysis in 81 patients with squamous cell carcinoma of the lung. Survival rate was modeled as function of AgNOR expression by Cox regression models controlled for staging, histologic grade, age, and sex. Our results indicate that AgNOR expression has a significant prognostic role. Tumors at lower stages have a lower expression of AgNOR than those with more advanced disease. Tumors with high histopathologic grade have a higher expression of AgNOR. Patients with low AgNOR expression presented a higher survival rate than those with higher amounts of AgNOR. The foregoing results strongly encourage the development of prospective trials to assess the real role of AgNOR in determining prognosis in squamous cell carcinoma of the lung.

Key Words: long-term survival • morphometry • nucleolar organizer region • squamous cell carcinoma of the lung

Submitted on September 12, 1995
Accepted on September 12, 1996






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