| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
Study objective: We compared the long-term safety and efficacy of the combination ipratropium bromide (IB) and albuterol sulfate (ALB) inhalation solution with that of each separate component using three-times-daily administration.
Design: Using a parallel design, we randomized patients to receive 3.0 mg ALB, 0.5 mg IB, or the combination by small-volume nebulizer (SVN) for 85 days. Subjects were allowed to use up to two extra doses of study medication daily for control of symptoms on an as-needed basis. The main efficacy evaluation was the acute pulmonary function response to an aerosol of the maintenance study medication over the course of the investigation. Physician global evaluation, subject quality of life assessments, COPD symptom scores, and twice-daily peak expiratory flow rate (PEFR) were also assessed over the study period.
Setting: Twenty-five centers participated in the investigation.
Patients: We studied 652 patients with moderate to severe COPD.
Measurements and results: Over the course of the study, the acute spirometric response and evening PEFR values with the SVN combination of IB plus ALB were statistically significantly better compared to ALB or IB alone. The quality of life scores, physician global evaluations, symptom scores, and morning PEFR scores were unchanged over the duration of the study in all treatment groups. There was no significant difference in adverse events in the three treatment groups.
Conclusions: In patients with COPD, maintenance SVN therapy with IB and ALB provides better bronchodilation than either therapy alone without increasing side effects.
Submitted on December 2, 1996
This article has been cited by other articles:
|
|
 |
|
  P. P. Walker, P. Mitchell, F. Diamantea, C. J. Warburton, and L. Davies Effect of primary-care spirometry on the diagnosis and management of COPD Eur. Respir. J., November 1, 2006; 28(5): 945 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. van Noord, J. L. Aumann, E. Janssens, J. Verhaert, J. J. Smeets, A. Mueller, and P. J. G. Cornelissen Effects of Tiotropium With and Without Formoterol on Airflow Obstruction and Resting Hyperinflation in Patients With COPD Chest, March 1, 2006; 129(3): 509 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Niewoehner, K. Rice, and S. Kesten Prevention of Exacerbations of Chronic Obstructive Pulmonary Disease with Tiotropium Ann Intern Med, January 17, 2006; 144(2): 148 - 149. [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Donohue Combination Therapy for Chronic Obstructive Pulmonary Disease: Clinical Aspects Proceedings of the ATS, November 1, 2005; 2(4): 272 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes and R. A. Stockley COPD: current therapeutic interventions and future approaches Eur. Respir. J., June 1, 2005; 25(6): 1084 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Sin, F. A. McAlister, S. F. P. Man, and N. R. Anthonisen Contemporary Management of Chronic Obstructive Pulmonary Disease: Scientific Review JAMA, November 5, 2003; 290(17): 2301 - 2312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Datta, A. Vitale, B. Lahiri, and R. ZuWallack An Evaluation of Nebulized Levalbuterol in Stable COPD Chest, September 1, 2003; 124(3): 844 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Croxton, G. G. Weinmann, R. M. Senior, R. A. Wise, J. D. Crapo, and A. S. Buist Clinical Research in Chronic Obstructive Pulmonary Disease: Needs and Opportunities Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1142 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D Sin and J. V Tu Lack of association between ipratropium bromide and mortality in elderly patients with chronic obstructive airway disease Thorax, March 1, 2000; 55(3): 194 - 197. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. A M Kerstjens Clinical evidence: Stable chronic obstructive pulmonary disease BMJ, August 21, 1999; 319(7208): 495 - 500. [Full Text]
|
|
|
|
|
|
G. Guyatt A 75-Year-Old Man With Congestive Heart Failure JAMA, June 23, 1999; 281(24): 2321 - 2328. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Dorinsky, C. Reisner, G. T. Ferguson, S. S. Menjoge, C. W. Serby, and T. J. Witek Jr. The Combination of Ipratropium and Albuterol Optimizes Pulmonary Function Reversibility Testing in Patients With COPD Chest, April 1, 1999; 115(4): 966 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Routine Addition of Ipratropium to Neb Treatment in COPD Journal Watch Emergency Medicine, February 1, 1998; 1998(201): 10 - 10. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
