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(Chest. 1998;113:584-586.)
© 1998 American College of Chest Physicians

Short-term Growth in Asthmatic Children Using Fluticasone Propionate

Martin J. Visser MD1; Wim M.C. van Aalderen MD1; Barbara M. Elliott Bsc2; Roelof J. Odink MD2; and Paul L.P. Brand MD1

1 From the Department of Pediatric Pulmonology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands
2 From the Pediatric Endocrinology, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands

Background: Inhaled corticosteroids may reduce short-term growth velocity in asthmatic children and knemometry is the most sensitive tool to detect this short-term growth suppression.

Study objective: To compare lower leg growth velocity, as measured by knemometry, in asthmatic children during and after treatment with inhaled fluticasone propionate (FP), 100 µg twice daily.

Design: Nonrandomized open trial.

Setting: University hospital, outpatient clinic for pediatric pulmonology.

Patients: Twenty-one asthmatic children (13 boys), aged 6 to 10 years.

Interventions: Inhalation of FP from a dry powder inhaler, 100 µg, twice daily for 6 weeks, followed by 2 weeks during which only an inhaled β2-agonist was used on demand (washout). During treatment and washout periods, patients were seen every 2 weeks at the same time of day.

Measurements and results: Lower leg growth velocity measured by knemometry during FP treatment was not significantly different from that during washout (p=0.33, one-way analysis of variance).

Conclusions: No significant suppression of lower leg growth velocity was found in prepubertal asthmatic children using FP, 100 µg, by dry powder inhaler twice daily for 6 weeks.

Key Words: asthma • children • fluticasone propionate • growth • inhaled corticosteroids • knemometry

Submitted on May 15, 1997
Accepted on August 28, 1997




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