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1 From the Service de Pneumologie et Réanimation Respiratoire and Service de Chirurgie Thoracique et Vasculaire, Hôpital Beaujon, Clichy, Unité Inserm 408, Paris, France
Background: Systemic hypotension may complicate the early postoperative period after lung transplantation. A release of proinflammatory cytokines secondary to lung ischemia/reperfusion injury could be involved in the pathogenesis of this early hemodynamic failure (EHF).
Study objective: To assess prospectively whether the occurrence of EHF is associated with a release of cytokines in the systemic circulation.
Design: Blood samples were taken daily during the first postoperative week in 26 patients who underwent a double or a single-lung transplantation. These patients were divided into three groups: 7 patients who experienced EHF and subsequently died (EHF group); 15 patients without EHF (control group); and 4 patients without EHF but with an identified sepsis (sepsis group). The serum levels of interleukin (IL)-1β, tumor necrosis factor-
(TNF-), IL-6, and IL-8 were compared among the three groups.
Results: In the EHF group, the levels of each cytokine peaked at day 1 postoperatively. Cytokine levels at day 1 were significantly higher in the EHF group than in the control group (p<0.0006) or in the sepsis group (p<0.003 except for TNF-).
Conclusion: We conclude that EHF is associated with a massive release of proinflammatory cytokines that could play a determinant role in the pathogenesis of this complication.
Key Words: cytokines • hypotension • lung transplantation • reperfusion injury • tumor necrosis factor
Submitted on April 17, 1997
Accepted on August 21, 1000
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