| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the British Columbia Cancer Agency, Vancouver, BC, Canada
2 From the Presbyterian/St Luke's Medical Center, University of Colorado Cancer Center, Denver
3 From the Pennsylvania Hospital, Philadelphia
4 From the Denver Veterans Affairs Medical Center, University of Colorado Cancer Center, Denver
5 From the University of Southern California/Kenneth Norris Jr. Cancer Center, Los Angeles
6 From the Memorial Sloan-Kettering Cancer Center, New York
7 From the University of California, Los Angeles
8 From the Evansville Cancer Center/St. Mary's Hospital, Evansville, Ind
9 From the Department of Pathology, British Columbia Cancer Research Centre, Vancouver, BC
10 From the Department of Epidemiology, British Columbia Cancer Research Centre, Vancouver, BC
11 From the Department of Pathology, Hamon Cancer Center, UT Southwestern Medical Center at Dallas
Background: In the treatment of lung cancer, the best outcome is achieved when the lesion is discovered in the intraepithelial (preinvasive) stage. However, intraepithelial neoplastic lesions are difficult to localize by conventional white-light bronchoscopy (WLB).
Objective: To determine if autofluorescence bronchoscopy, when used as an adjunct to WLB, could improve the bronchoscopist's ability to locate and remove biopsy specimens from areas suspicious of intraepithelial neoplasia as compared with WLB alone.
Method: A multicenter clinical trial was conducted in seven institutions in the United States and Canada. WLB followed by fluorescence examination with the light-induced fluorescence endoscopy (LIFE) device was performed in 173 subjects known or suspected to have lung cancer. Biopsy specimens were taken from all areas suspicious of moderate dysplasia or worse on WLB and/or LIFE examination. In addition, random biopsy specimens were also taken from other parts of the bronchial tree.
Results: The relative sensitivity of WLB+LIFE vs WLB alone was 6.3 for intraepithelial neoplastic lesions and 2.71 when invasive carcinomas were also included. The positive predictive value was 0.33 and 0.39 and the negative predictive value was 0.89 and 0.83, respectively, for WLB+LIFE and WLB alone.
Conclusion: Autofluorescence bronchoscopy, when used as an adjunct to standard WLB, enhances the bronchoscopist's ability to localize small neoplastic lesions, especially intraepithelial lesions that may have significant implication in the management of lung cancer in the future.
Key Words: autofluorescence • bronchoscopy • early detection • lung neoplasm
Submitted on June 17, 1997
Accepted on August 29, 1000
This article has been cited by other articles:
|
|
 |
|
  M. Pilichowska, S. Klepper, G. Campbell, A. Klein, A. Ernst, and G. Finlay A 64-Year-Old Woman With Cough and Right Middle Lobe Collapse Chest, November 1, 2007; 132(5): 1691 - 1696. [Full Text] [PDF]
|
|
|
|
|
|
B. D. Vincent, M. Fraig, and G. A. Silvestri A Pilot Study of Narrow-Band Imaging Compared to White Light Bronchoscopy for Evaluation of Normal Airways and Premalignant and Malignant Airways Disease Chest, June 1, 2007; 131(6): 1794 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Lonergan, R. Chari, R. J. deLeeuw, A. Shadeo, B. Chi, M.-S. Tsao, S. Jones, M. Marra, V. Ling, R. Ng, et al. Identification of Novel Lung Genes in Bronchial Epithelium by Serial Analysis of Gene Expression Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 651 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Lam, M. P. Wong, S. L. Fung, D. C. L. Lam, P. C. Wong, T. Y. W. Mok, F. M. Lam, M. S. M. Ip, C. G. C. Ooi, and W. K. Lam The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer Eur. Respir. J., November 1, 2006; 28(5): 915 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J-M. Vergnon, R. M. Huber, and K. Moghissi Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur. Respir. J., July 1, 2006; 28(1): 200 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. L. Bard, A. Amelink, M. Skurichina, V. Noordhoek Hegt, R. P. W. Duin, H. J. C. M. Sterenborg, H. C. Hoogsteden, and J. G. J. V. Aerts Optical spectroscopy for the classification of malignant lesions of the bronchial tree. Chest, April 1, 2006; 129(4): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K-C Chang, C-C Leung, and C-M Tam Per lesion analysis is misleading. Thorax, April 1, 2006; 61(4): 364 - 364. [Full Text] [PDF]
|
|
|
|
 |
|
 D. Feller-Kopman, W. Lunn, and A. Ernst Autofluorescence Bronchoscopy and Endobronchial Ultrasound: A Practical Review Ann. Thorac. Surg., December 1, 2005; 80(6): 2395 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Furukawa, H. Kato, C. Konaka, T. Okunaka, J. Usuda, and Y. Ebihara Locally Recurrent Central-Type Early Stage Lung Cancer < 1.0 cm in Diameter After Complete Remission by Photodynamic Therapy Chest, November 1, 2005; 128(5): 3269 - 3275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. M. Miyazu, T. Miyazawa, K. Hiyama, N. Kurimoto, Y. Iwamoto, H. Matsuura, K. Kanoh, N. Kohno, M. Nishiyama, and E. Hiyama Telomerase Expression in Noncancerous Bronchial Epithelia Is a Possible Marker of Early Development of Lung Cancer Cancer Res., November 1, 2005; 65(21): 9623 - 9627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. E. Miller Pathogenesis of Lung Cancer: 100 Year Report Am. J. Respir. Cell Mol. Biol., September 1, 2005; 33(3): 216 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Moghissi and K. Dixon Photodynamic therapy for synchronous occult bronchial cancer 17 years after pneumonectomy Interactive CardioVascular and Thoracic Surgery, August 1, 2005; 4(4): 327 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Chhajed, K. Shibuya, H. Hoshino, M. Chiyo, K. Yasufuku, K. Hiroshima, and T. Fujisawa A comparison of video and autofluorescence bronchoscopy in patients at high risk of lung cancer Eur. Respir. J., June 1, 2005; 25(6): 951 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Haussinger, H Becker, F Stanzel, A Kreuzer, B Schmidt, J Strausz, S Cavaliere, F Herth, M Kohlhaufl, K-M Muller, et al. Autofluorescence bronchoscopy with white light bronchoscopy compared with white light bronchoscopy alone for the detection of precancerous lesions: a European randomised controlled multicentre trial Thorax, June 1, 2005; 60(6): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lam, J. C. leRiche, A. McWilliams, C. MacAulay, Y. Dyachkova, E. Szabo, J. Mayo, R. Schellenberg, A. Coldman, E. Hawk, et al. A Randomized Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) in People with Dysplasia of the Bronchial Epithelium Clin. Cancer Res., October 1, 2004; 10(19): 6502 - 6511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ruffini, M. Bongiovanni, A. Cavallo, P.L. Filosso, R. Giobbe, M. Mancuso, M. Molinatti, and A. Oliaro The significance of associated pre-invasive lesions in patients resected for primary lung neoplasms Eur. J. Cardiothorac. Surg., July 1, 2004; 26(1): 165 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Banerjee, P. H. Rabbitts, and P. J. George Preinvasive Bronchial Lesions: Surveillance or Intervention? Chest, May 1, 2004; 125(5_suppl): 95S - 96S. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Jett and D. E. Midthun Screening for Lung Cancer: Current Status and Future Directions: Thomas A. Neff Lecture Chest, May 1, 2004; 125(5_suppl): 158S - 162S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al. American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003 J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353. [Full Text] [PDF]
|
|
|
|
|
|
M. Means-Markwell, R. I. Linnoila, J. Williams, P. A. Janne, F. Kaye, K. O'Neil, and B. E. Johnson Prospective Study of the Airways and Pulmonary Parenchyma of Patients at Risk for a Second Lung Cancer Clin. Cancer Res., December 1, 2003; 9(16): 5915 - 5921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Sidransky, R. Irizarry, J. A. Califano, X. Li, H. Ren, N. Benoit, and L. Mao Serum Protein MALDI Profiling to Distinguish Upper Aerodigestive Tract Cancer Patients From Control Subjects J Natl Cancer Inst, November 19, 2003; 95(22): 1711 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. McWilliams, J. Mayo, S. MacDonald, J. C. leRiche, B. Palcic, E. Szabo, and S. Lam Lung Cancer Screening: A Different Paradigm Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1167 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Shibuya, H Hoshino, M Chiyo, A Iyoda, S Yoshida, Y Sekine, T Iizasa, Y Saitoh, M Baba, K Hiroshima, et al. High magnification bronchovideoscopy combined with narrow band imaging could detect capillary loops of angiogenic squamous dysplasia in heavy smokers at high risk for lung cancer Thorax, November 1, 2003; 58(11): 989 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Moghissi and K. Dixon Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer? Eur. Respir. J., September 1, 2003; 22(3): 535 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Tsao, T. McDonnell, S. Lam, J. B. Putnam, N. Bekele, W. K. Hong, and J. M. Kurie Increased Phospho-AKT (Ser473) Expression in Bronchial Dysplasia: Implications for Lung Cancer Prevention Studies Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 660 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A-P. Meert, J-M. Verdebout, B. Martin, V. Ninane, F. Feoli, and J-P. Sculier Epidermal growth factor receptor expression in pre-invasive and early invasive bronchial lesions Eur. Respir. J., April 1, 2003; 21(4): 611 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A K Banerjee, P H Rabbitts, and J George Lung cancer * 3: Fluorescence bronchoscopy: clinical dilemmas and research opportunities Thorax, March 1, 2003; 58(3): 266 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brambilla, F. Fievet, M. Jeanmart, F. de Fraipont, S. Lantuejoul, V. Frappat, G. Ferretti, P.Y. Brichon, and D. Moro-Sibilot Early detection of lung cancer: role of biomarkers Eur. Respir. J., January 1, 2003; 21(39_suppl): 36S - 44s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Sutedja New techniques for early detection of lung cancer Eur. Respir. J., January 1, 2003; 21(39_suppl): 57S - 66s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Dragnev, D. Stover, and E. Dmitrovsky Lung Cancer Prevention: The Guidelines Chest, January 1, 2003; 123(1_suppl): 60S - 71S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Moro-Sibilot, M. Jeanmart, S. Lantuejoul, F. Arbib, M. H. Laverriere, E. Brambilla, and C. Brambilla Cigarette Smoking, Preinvasive Bronchial Lesions, and Autofluorescence Bronchoscopy Chest, December 1, 2002; 122(6): 1902 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Mehta Don't Lose the Forest for the Trees: Satisfaction and Success in Bronchoscopy Am. J. Respir. Crit. Care Med., November 15, 2002; 166(10): 1306 - 1307. [Full Text] [PDF]
|
|
|
|
|
|
S. G. Spiro and J. C. Porter Lung Cancer--Where Are We Today?: Current Advances in Staging and Nonsurgical Treatment Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1166 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Shibuya, H Hoshino, M Chiyo, K Yasufuku, T Iizasa, Y Saitoh, M Baba, K Hiroshima, H Ohwada, and T Fujisawa Subepithelial vascular patterns in bronchial dysplasias using a high magnification bronchovideoscope Thorax, October 1, 2002; 57(10): 902 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lam, C. MacAulay, J. C. le Riche, Y. Dyachkova, A. Coldman, M. Guillaud, E. Hawk, M.-O. Christen, and A. F. Gazdar A Randomized Phase IIb Trial of Anethole Dithiolethione in Smokers with Bronchial Dysplasia J Natl Cancer Inst, July 3, 2002; 94(13): 1001 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. MIYAZU, T. MIYAZAWA, N. KURIMOTO, Y. IWAMOTO, K. KANOH, and N. KOHNO Endobronchial Ultrasonography in the Assessment of Centrally Located Early-Stage Lung Cancer before Photodynamic Therapy Am. J. Respir. Crit. Care Med., March 15, 2002; 165(6): 832 - 837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.F. Beamis, H.D. Becker, S. Cavaliere, H. Colt, J.P. Diaz-Jimenez, J.F. Dumon, E. Edell, K.L. Kovitz, H.N. Macha, A.C. Mehta, et al. ERS/ATS statement on interventional pulmonology: Chairmen: C.T. Bolliger, P.N. Mathur Eur. Respir. J., February 1, 2002; 19(2): 356 - 373. [Full Text] [PDF]
|
|
|
|
|
|
T. L. Weigel, V. W. Rusch, and J. D. Luketich Postoperative fluorescence bronchoscopic surveillance: a worthwhile procedure in a subset of patients: Reply Ann. Thorac. Surg., January 1, 2002; 73(1): 348 - 348. [Full Text] [PDF]
|
|
|
|
|
|
S. BOTA, J.-B. AULIAC, C. PARIS, J. METAYER, R. SESBOUE, G. NOUVET, and L. THIBERVILLE Follow-up of Bronchial Precancerous Lesions and Carcinoma in Situ Using Fluorescence Endoscopy Am. J. Respir. Crit. Care Med., November 1, 2001; 164(9): 1688 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Sutedja, H. Codrington, E. K. Risse, R. H. Breuer, J. C. van Mourik, R. P. Golding, and P. E. Postmus Autofluorescence Bronchoscopy Improves Staging of Radiographically Occult Lung Cancer and Has an Impact on Therapeutic Strategy Chest, October 1, 2001; 120(4): 1327 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Hirsch, S. A. Prindiville, Y. E. Miller, W. A. Franklin, E. C. Dempsey, J. R. Murphy, P. A. Bunn Jr., and T. C. Kennedy Fluorescence Versus White-Light Bronchoscopy for Detection of Preneoplastic Lesions: a Randomized Study J Natl Cancer Inst, September 19, 2001; 93(18): 1385 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Kennedy, S. Lam, and F. R. Hirsch Review of Recent Advances in Fluorescence Bronchoscopy in Early Localization of Central Airway Lung Cancer Oncologist, June 1, 2001; 6(3): 257 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zöchbauer-Müller, K. M. Fong, A. Maitra, S. Lam, J. Geradts, R. Ashfaq, A. K. Virmani, S. Milchgrub, A. F. Gazdar, and J. D. Minna 5' CpG Island Methylation of the FHIT Gene Is Correlated with Loss of Gene Expression in Lung and Breast Cancer Cancer Res., May 1, 2001; 61(9): 3581 - 3585. [Abstract] [Full Text]
|
|
|
|
|
|
T. L. Weigel, P. J. Kosco, S. Dacic, V. W. Rusch, R. J. Ginsberg, and J. D. Luketich Postoperative fluorescence bronchoscopic surveillance in non-small cell lung cancer patients Ann. Thorac. Surg., March 1, 2001; 71(3): 967 - 970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Hirsch, W. A. Franklin, A. F. Gazdar, and P. A. Bunn Jr. Early Detection of Lung Cancer: Clinical Perspectives of Recent Advances in Biology and Radiology Clin. Cancer Res., January 1, 2001; 7(1): 5 - 22. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. F. Patz, P. C. Goodman, and G. Bepler Screening for Lung Cancer N. Engl. J. Med., November 30, 2000; 343(22): 1627 - 1633. [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Boiselle, A. Ernst, and D. D. Karp Lung Cancer Detection in the 21st Century: Potential Contributions and Challenges of Emerging Technologies Am. J. Roentgenol., November 1, 2000; 175(5): 1215 - 1221. [Full Text] [PDF]
|
|
|
|
 |
|
 T. L. Petty Screening Strategies for Early Detection of Lung Cancer: The Time Is Now JAMA, October 18, 2000; 284(15): 1977 - 1980. [Full Text] [PDF]
|
|
|
|
|
|
B. J. W. Venmans, T. J. M. van Boxem, E. F. Smit, P. E. Postmus, and T. G. Sutedja Outcome of Bronchial Carcinoma In Situ Chest, June 1, 2000; 117(6): 1572 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Massard, C. Doddoli, B. Gasser, X. Ducrocq, R. Kessler, C. Schumacher, G.-M. Jung, and J.-M. Wihlm Prognostic implications of a positive bronchial resection margin Eur. J. Cardiothorac. Surg., May 1, 2000; 17(5): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Gazdar and J. D. Minna Angiogenesis and the Multistage Development of Lung Cancers Clin. Cancer Res., May 1, 2000; 6(5): 1611 - 1612. [Full Text]
|
|
|
|
|
|
R. L. Keith, Y. E. Miller, R. M. Gemmill, H. A. Drabkin, E. C. Dempsey, T. C. Kennedy, S. Prindiville, and W. A. Franklin Angiogenic Squamous Dysplasia in Bronchi of Individuals at High Risk for Lung Cancer Clin. Cancer Res., May 1, 2000; 6(5): 1616 - 1625. [Abstract] [Full Text]
|
|
|
|
|
|
I. I. Wistuba, C. Behrens, A. K. Virmani, G. Mele, S. Milchgrub, L. Girard, J. W. Fondon III, H. R. Garner, B. McKay, F. Latif, et al. High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and Preneoplastic/Preinvasive Bronchial Epithelium Reveals Multiple, Discontinuous Sites of 3p Allele Loss and Three Regions of Frequent Breakpoints Cancer Res., April 1, 2000; 60(7): 1949 - 1960. [Abstract] [Full Text]
|
|
|
|
|
|
W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG Molecular and Genetic Aspects of Lung Cancer Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1355 - 1367. [Full Text]
|
|
|
|
|
|
T. C. Kennedy, Y. Miller, and S. Prindiville Screening for Lung Cancer Revisited and the Role of Sputum Cytology and Fluorescence Bronchoscopy in a High-Risk Group Chest, April 1, 2000; 117(4_suppl_1): 72S - 79S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pierard, P. Vermylen, T. Bosschaerts, C. Roufosse, T. Berghmans, J.-P. Sculier, and V. Ninane Synchronous Roentgenographically Occult Lung Carcinoma in Patients With Resectable Primary Lung Cancer Chest, March 1, 2000; 117(3): 779 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Petty It's Time to Pick the Low-Hanging Fruit Chest, January 1, 2000; 117(1): 1 - 2. [Full Text] [PDF]
|
|
|
|
|
|
U. B. S. Prakash Advances in Bronchoscopic Procedures Chest, November 1, 1999; 116(5): 1403 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lam, J. C. leRiche, Y. Zheng, A. Coldman, C. MacAulay, E. Hawk, G. Kelloff, and A. F. Gazdar Sex-Related Differences in Bronchial Epithelial Changes Associated With Tobacco Smoking J Natl Cancer Inst, April 21, 1999; 91(8): 691 - 696. [Abstract] [Full Text] [PDF]
|
