| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
1 From the Departments of Thoracic Surgery, Saiseikai Central Hospital, Tokyo
2 From the Department of Medicine, Saiseikai Central Hospital, Tokyo
3 From the Department of Pathology, Saiseikai Central Hospital, Tokyo
Study objectives: To examine the characteristics of peripheral lung adenocarcinomas diagnosed by open lung or video-assisted thoracoscopic surgery (VATS) biopsy.
Design: We used retrospective analysis to compare tumor stage, pleural involvement, central tumor fibrosis, and the number of bronchi or vessels involved with tumors of small peripheral lung adenocarcinomas diagnosed by bronchoscopic biopsy.
Patients: Subjects had lung adenocarcinomas diagnosed by open lung or VATS (n=22) and those diagnosed by bronchoscopic biopsy (n=22), which were matched by tumor size.
Results: The T1N0M0 tumor was notably more frequent in the open lung or VATS group (77.3%) than in the bronchoscopic biopsy group (36.4%) (p<0.01). Tumors invading beyond the pleural surface were less frequent in the open lung or VATS group (4.5%) than in the bronchoscopic biopsy group (40.9%) (p<0.01). The grade of in-tumor central fibrosis—a malignancy factor and the cause of bronchi or vessel involvement with tumors—was significantly lower in the open lung or VATS group than in the bronchoscopic biopsy group (p<0.01). The number of bronchi or vessels involved with tumors was significantly fewer in the open lung or VATS group than in the bronchoscopic biopsy group (p<0.001).
Conclusions: (1) Lung adenocarcinomas diagnosed by open lung or VATS biopsy were more frequently T1N0M0 than those diagnosed by bronchoscopic biopsy, which was caused by low grade of central tumor fibrosis rather than small tumor size. (2) They were infrequently diagnosed by bronchoscopic biopsy because few bronchi were involved by tumors due to the low grade of central tumor fibrosis. (3) Small pulmonary nodules not diagnosable by bronchoscopic biopsy should be diagnosed aggressively using VATS biopsy to detect early-stage lung cancer.
Key Words: adenocarcinoma • biopsy • bronchoscopy • non-small cell lung cancer • video-assisted thoracoscopic surgery
Submitted on July 31, 1997
Accepted on December 9, 1997
This article has been cited by other articles:
|
|
 |
|
  N. Durrleman and G. Massard Antero-lateral thoracotomy MMCTS, August 10, 2006; 2006(0810): 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nakajima, H. Sato, and S. Takamoto Does Preoperative Transbronchial Biopsy Worsen the Postsurgical Prognosis of Lung Cancer?: A Propensity Score-Adjusted Analysis Chest, November 1, 2005; 128(5): 3512 - 3518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cho, D. Kim, S. Lee, and Y. Lee Cobalt Chloride-Induced Estrogen Receptor {alpha} Down-Regulation Involves Hypoxia-Inducible Factor-1{alpha} in MCF-7 Human Breast Cancer Cells Mol. Endocrinol., May 1, 2005; 19(5): 1191 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Suemasu, and K. Uno Visual and Semiquantitative Analyses for F-18 Fluorodeoxyglucose PET Scanning in Pulmonary Nodules 1 cm to 3 cm in Size Ann. Thorac. Surg., March 1, 2005; 79(3): 984 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nakajima, S. Takamoto, J. Matsumoto, E. Takeuchi, and Y. M Ito Effect of Preoperative Transbronchial Biopsy on Prognosis of Non-small Cell Lung Cancer Asian Cardiovasc Thorac Ann, December 1, 2004; 12(4): 330 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nomori, K. Watanabe, T. Ohtsuka, T. Naruke, K. Suemasu, T. Kobayashi, and K. Uno Fluorine 18-tagged fluorodeoxyglucose positron emission tomographic scanning to predict lymph node metastasis, invasiveness, or both, in clinical T1 N0 M0 lung adenocarcinoma J. Thorac. Cardiovasc. Surg., September 1, 2004; 128(3): 396 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Funakoshi, N. Sawabata, S.-i. Takeda, Y. Okumura, M. Hayakawa, and H. Maeda Bronchoscopically undiagnosed small peripheral lung tumors Interactive CardioVascular and Thoracic Surgery, December 1, 2003; 2(4): 517 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu Histogram analysis of computed tomography numbers of clinical T1 N0 M0 lung adenocarcinoma, with special reference to lymph node metastasis and tumor invasiveness J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1584 - 1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nomori, T. Ohtsuka, T. Naruke, and K. Suemasu Differentiating between atypical adenomatous hyperplasia and bronchioloalveolar carcinoma using the computed tomography number histogram Ann. Thorac. Surg., September 1, 2003; 76(3): 867 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Ambrosini, A. K. Nath, M. R. Sierra-Honigmann, and J. Flores-Riveros Transcriptional Activation of the Human Leptin Gene in Response to Hypoxia. INVOLVEMENT OF HYPOXIA-INDUCIBLE FACTOR 1 J. Biol. Chem., September 6, 2002; 277(37): 34601 - 34609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sawabata, H. Maeda, M. Ohta, and M. Hayakawa Operable Non-small Cell Lung Cancer Diagnosed by Transpleural Techniques : Do They Affect Relapse and Prognosis? Chest, November 1, 2001; 120(5): 1595 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Olfert, E. C. Breen, O. Mathieu-Costello, and P. D. Wagner Chronic hypoxia attenuates resting and exercise-induced VEGF, flt-1, and flk-1 mRNA levels in skeletal muscle J Appl Physiol, April 1, 2001; 90(4): 1532 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Williams and P. D. Wagner Transgenic animals in integrative biology: approaches and interpretations of outcome J Appl Physiol, March 1, 2000; 88(3): 1119 - 1126. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
