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(Chest. 1998;114:495-499.)
© 1998 American College of Chest Physicians

Bronchial Responsiveness and Angiotensin-Converting Enzyme Gene Polymorphism in Sarcoidosis Patients

Takashi Niimi MD1; Hiroshi Tomita MD1; Shigeki Sato MD1; Toshiyuki Mori MD1; Haruhiko Kawaguchi MD1; Yoshiki Sugiura MD1; and Ryohei Matsuda MD1

1 From the 2nd Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

Dr. Takashi Niimi, 2nd Department of Internal Medicine, Nagoya City University Medical School, Kawasumi 1, Mizuho-ku, Nagoya-city, Aichi 467-8601, Japan

Background: Angiotensin-converting enzyme (ACE) inactivates bradykinin and tachykinins, which are potent bronchoconstrictors and mediators of inflammatory reactions. It has recently been shown that an insertion (I)/deletion (D) polymorphism in the ACE gene accounts for variation in serum ACE level. We investigated bronchial responsiveness in patients with sarcoidosis to determine whether it might be associated with ACE gene polymorphism.

Subjects: Bronchial responsiveness was assessed in 21 patients with sarcoidosis, 21 patients with asthma, and 18 healthy control subjects. ACE polymorphism was also examined in the 21 patients with sarcoidosis.

Methods: Bronchial responsiveness was measured by recording respiratory resistance with continuous inhalation of methacholine from 49 to 25,000 µg/mL in concentration. The ACE genotype was determined using the polymerase chain reaction.

Results: We found a significant increase in bronchial responsiveness in sarcoidosis patients as compared with healthy control subjects (p<0.01). In the sarcoidosis group, patients with the II genotype demonstrated significantly more coughing (p<0.05) and a greater bronchial responsiveness (p<0.05) than did those with DI or DD genotypes.

Conclusion: Patients with sarcoidosis have increased bronchial responsiveness to some extent, the degree apparently depending on the ACE genotype.

Key Words: angiotensin-converting enzyme • bradykinin • bronchial responsiveness • gene • polymorphism • sarcoidosis • tachykinin

Submitted on August 13, 1997
Accepted on January 22, 1998




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