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(Chest. 1998;114:521-525.)
© 1998 American College of Chest Physicians

Long-term Within-Subject Variability of Inspiratory Neural Drive Response to Hypoxia

Francisco García-Río PhD1; José M. Pino-García PhD1; Miguel A. Racionero MD1; Javier G. Terreros-Caro MD1; María A. Gómez-Mendieta MD1; Concepción Prados PhD1; and Carlos Villasante MD1

1 From the Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain

Study objective: We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects.

Patients and interventions: We studied 21 healthy subjects (14 male and 7 female; aged 40±12 yrs) (mean±SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions.

Results: There was no significant change in clinical condition, FVC, FEV1 arterial oxygenation saturation, end-tidal and mixed venous PCO2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032±0.022 and 0.034±0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented.

Conclusion: Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity.

Key Words: carotid body • hypoxia • respiratory center • variability

Submitted on August 25, 1997
Accepted on January 21, 1998




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