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(Chest. 1998;114:1033-1035.)
© 1998 American College of Chest Physicians

Reduction of Diffusion Capacity for Carbon Monoxide in Diabetic Patients

Spomenka Ljubicacute MD, MSc1; Zcaroneljko Metelko MD, PhD1; Nikica Car MD, PhD1; Gojka Roglicacute MD1; and Zrinka Drazcaronicacute MD1

1 From the Vuk Vrhovac Institute, University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Zagreb, Croatia

Spomenka Ljubicacute, Vuk Vrhovac Institute, Dugi Dol 4a, 10000 Zagreb, Croatia

Diabetes can cause the development of pulmonary complications due to collagen and elastin changes, as well as microangiopathy. This study demonstrates the relationship between pulmonary complications and other chronic complications in diabetes. Twenty-seven patients with diabetes, aged 21 to 62 years, who had had the disease from 3 to 32 years, were included in this study. The protein excretion rate (PER) and the diffusion capacity of the lung for carbon monoxide (DLCO) were included as parameters of the severity of complications. PER was determined by the Biuret method. DLCO was measured by the single-breath method and was corrected by the measurement of alveolar volume (VA). The values of DLCO as corrected by VA (DLCO/VA) were included in the statistical evaluation of the results. The variables of age, duration of diabetes, and complication parameters were included in a multiple regression model with forward, stepwise selection to assess their value in predicting DLCO/VA. The variables were found to be significant predictors of DLCO/VA (R2 = 0.46, adjusted R2 = 0.32, p < 0.022). However, proteinuria was the only significant independent predictor of DLCO/VA. This finding indicates that both renal and pulmonary complications of diabetes share a similar microangiopathic background.

Key Words: diabetes mellitus • diffusion capacity of the lung for carbon monoxide corrected by alveolar volume • protein excretion rate

Submitted on February 19, 1997
Accepted on April 6, 1998




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