| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
* From the Foothills Medical Centre, Calgary, Alberta, Canada.
Objective: To identify and critically review the published peer-reviewed, English-language studies of the effects of both spontaneous and simulated gastroesophageal reflux (GER) on pulmonary function in asthmatic adults.
Design: Using the 1966 to 1997 MEDLINE database, the terms asthma and lung disease were combined with GER to identify studies of the effects of GER and acid perfusion (AP) of the esophagus on pulmonary function. The bibliographies were also reviewed. Studies of asthmatics with and without symptomatic GER were analyzed both together and separately.
Results: A total of 254 citations,
including 180 published in English, were identified. Among these were
18 studies of GER and AP in asthmatic adults. These reports, which
contain data on 312 asthmatics, found that the FEV1 and the
midexpiratory rate did not change during AP and GER in the
studies containing 97% and 94% of the asthmatics,
respectively. Flow volume loop indexes, including the flow at
50% of the vital capacity (
50), flow at 25% of the
vital capacity, and the peak expiratory flow rate, did not change
during AP or GER in the studies with 77%, 60%, and 65% of the
asthmatics, respectively. Small changes in the resistance were reported
in the studies containing 42% of the asthmatics. Among asthmatics
without symptomatic GER, no changes in spirometry, resistance, and flow
volume indexes were found, except for a 10% decline in
50 in one study with seven subjects.
Conclusions: In asthmatics with GER, the effects of AP on pulmonary function are minimal, and only a minority are affected. The literature does not support the conclusion that asymptomatic reflux contributes to worsening lung function.
Key Words: airway resistance • asthma • atypical chest pain • bronchial reactivity • cough • dyspnea • gastroesophageal reflux • heartburn • pulmonary function
This article has been cited by other articles:
|
|
 |
|
  A. M. Ravelli, M. B. Panarotto, L. Verdoni, V. Consolati, and S. Bolognini Pulmonary Aspiration Shown by Scintigraphy in Gastroesophageal Reflux-Related Respiratory Disease. Chest, November 1, 2006; 130(5): 1520 - 1526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Schachter, J. Dixon, R. J. Pierce, and P. O'Brien Severe Gastroesophageal Reflux Is Associated With Reduced Carbon Monoxide Diffusing Capacity Chest, June 1, 2003; 123(6): 1932 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-N. Wu, K. Yamauchi, H. Kobayashi, Y. Tanifuji, C. Kato, K. Suzuki, and H. Inoue Effects of Esophageal Acid Perfusion on Cough Responsiveness in Patients With Bronchial Asthma* Chest, August 1, 2002; 122(2): 505 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Field Asthma and Gastroesophageal Reflux : Another Piece in the Puzzle? Chest, April 1, 2002; 121(4): 1024 - 1027. [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Greason, D. L. Miller, C. Deschamps, M. S. Allen, F. C. Nichols III, V. F. Trastek, and P. C. Pairolero Effects of antireflux procedures on respiratory symptoms Ann. Thorac. Surg., February 1, 2002; 73(2): 381 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Lazenby, M. R. Guzzo, S. M. Harding, P. E. Patterson, L. F. Johnson, and L. A. Bradley Oral Corticosteroids Increase Esophageal Acid Contact Times in Patients With Stable Asthma Chest, February 1, 2002; 121(2): 625 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S K FIELD, L R SUTHERLAND, and P GIBSON Gastro-oesophageal reflux and asthma Thorax, November 1, 2001; 56(11): 898 - 898. [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. THEODOROPOULOS, D. K. LEDFORD, R. F. LOCKEY, D. L. PECORARO, J. A. RODRIGUEZ, M. C. JOHNSON, and H. W. BOYCE Jr. Prevalence of Upper Respiratory Symptoms in Patients with Symptomatic Gastroesophageal Reflux Disease Am. J. Respir. Crit. Care Med., July 1, 2001; 164(1): 72 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mokhlesi, A. L. Morris, C.-F. Huang, A. J. Curcio, T. A. Barrett, and D. W. Kamp Increased Prevalence of Gastroesophageal Reflux Symptoms in Patients With COPD Chest, April 1, 2001; 119(4): 1043 - 1048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J L Coughlan, P G Gibson, and R L Henry Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review Thorax, March 1, 2001; 56(3): 198 - 204. [Abstract] [Full Text]
|
|
|
|
|
|
S. K. Field, G. A. J. Gelfand, and S. D. McFadden The Effects of Antireflux Surgery on Asthmatics With Gastroesophageal Reflux Chest, September 1, 1999; 116(3): 766 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Field Gastroesophageal Reflux and Respiratory Symptoms Chest, September 1, 1999; 116(3): 843 - 843. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
