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(Chest. 1999;115:1452-1455.)
© 1999 American College of Chest Physicians

Pulmonary Langerhans' Cell Histiocytosis*

Radiologic Resolution Following Smoking Cessation

Nesrin Mogulkoc, MD; Ali Veral, MD; Paul W. Bishop, MB, BCh; Ülkü Bayindir, MD; C. Anthony C. Pickering, MD and Jim J. Egan, MD

* From Ege University Hospital, (Drs. Mogulkoc, Veral, and Bayindir), Izmir, Turkey; and Wythenshawe Hospital, (Drs. Bishop, Pickering, and Egan), Manchester, UK.

Correspondence to: Nesrin Mogulkoc, MD, North West Lung Research Center, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, United Kingdom; e-mail: 100046.1102{at}compuserve.com

We describe two patients with histologically proven pulmonary Langerhans' cell histiocytosis in whom radiologic improvement occurred following smoking cessation. The patients had 23- and 25-pack-year smoking histories, respectively. High-resolution CT revealed multiple small nodules, located predominantly in the upper and middle lung fields. There was a close temporal relationship between smoking cessation and radiologic improvement.

Key Words: Langerhans' cell granulomatosis • Langerhans' cell histiocytosis (LCH) • pulmonary histiocytosis X • smoking cessation




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