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* From the National Adult Cystic Fibrosis Unit, Department of Respiratory Medicine, St. Vincent's University Hospital, Dublin, Ireland.
Correspondence to: C. G. Gallagher, MD, FCCP, Department of Respiratory Medicine, St. Vincent's University Hospital, Dublin 4, Republic of Ireland; e-mail: cgall{at}indigo.ie
Objectives: Exercise testing in patients with cystic fibrosis (CF) has become an important tool in assessing disease severity and predicting overall outcome. The reproducibility of maximal exercise testing was examined in adult subjects with stable CF.
Methods: Nine subjects with CF underwent a total of three
maximal exercise tests carried out under identical circumstances over a
28-day period. Oxygen uptake
(
O2), minute
ventilation (E), respiratory frequency (f), heart
rate (HR), and arterial oxygen saturation
(SaO2) were measured at rest, at end exercise,
and at 40% and 70% of maximum workload.
Results:
There were no significant differences in these measurements among the
three tests. Reproducibility of exercise performance was assessed using
the coefficient of variation. The mean within-subject coefficient of
variation for test variables at end exercise are as follows:
O2, 6.9%;
E, 6.2%; f, 5.8%; HR, 3.0%; and
SaO2, 1.1%. The mean within-subject
coefficient of variation for test variables at 40% and 70% of maximal
work rates are as follows:
O2, 5.2% and 4.6%;
SaO2, 0.3% and 0.9%; HR, 4.0% and 3%;
E, 5.7% and 6.5%; and f, 5.8% and 7.2%,
respectively.
Conclusions: Variables measured during clinical cycle ergometer exercise testing in adult patients with stable CF are reproducible. No learning effect was found on repeated testing.
Key Words: cystic fibrosis • exercise testing • reproducibility
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