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Interferon- Therapy Associated With the Development of Sarcoidosis^*

^* From the Pulmonary and Critical Care Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY.

Correspondence to: Anthony P. Pietropaoli, MD, Pulmonary and Critical Care Unit, University of Rochester Medical Center, 601 Elmwood Ave, Box 692, Rochester, NY 14642-8692; e-mail: Anthony Pietropaoli{at}URMC.rochester.eduPietropaoli@URMC.rochester.edu

Interferons (IFNs) have been implicated in the pathogenesis of sarcoidosis. In particular, IFN- has been linked to pulmonary macrophage activation, a characteristic feature of sarcoidosis. IFN- is now being administered therapeutically in a variety of conditions. To date, IFN- has not been implicated in the pathogenesis of sarcoidosis. We report the case of a 50-year-old woman who developed sarcoidosis while being treated with IFN- for chronic myelogenous leukemia. Her disease activity correlated with the dosage of IFN-. We speculate that the immunomodulatory effects of IFN- triggered clinical manifestations of sarcoidosis in this patient.

Key Words: autoimmune disease • interferon- • sarcoidosis

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