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(Chest. 1999;116:572-574.)
© 1999 American College of Chest Physicians

Disseminated Pseudallescheria boydii Infection in a Nonimmunocompromised Host*

Abid Khurshid, MD, FCCP; V. Theodore Barnett, MD, FCCP; Marin Sekosan, MD; Alan S. Ginzburg, MD, FCCP and Ergün Önal, MD

* From the Department of Medicine (Drs. Khurshid, Barnett, Ginzberg, and Önal), Section of Respiratory and Critical Care Medicine, and the Department of Pathology (Dr. Sekosan), University of Illinois, College of Medicine at Chicago, and the Veterans Administration West Side Medical Center, Chicago, IL.

Correspondence to: Abid Khurshid, MD, FCCP, Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Loyola University Medical Center, 2160 S First Ave, Bldg 54, Room 123, Maywood, IL 60153; e-mail: akhursh{at}luc.edu

We present a highly unusual case of pulmonary Pseudallescheria boydii infection in a nonimmunocompromised host with a cavitating mass lesion. The diagnosis was confirmed by open lung biopsy. The patient was treated at another institution with a course of amphotericin B, considered an ineffective therapy for this infection, and presented to us with direct extension and invasion of the left atrial appendage and the pulmonary artery, followed by massive pulmonary embolization and hematogenous dissemination to the liver, spleen, kidney, pancreas, and brain.

Key Words: fungal hematogenous dissemination • fungal pulmonary embolism • nonimmunocompromised host • Pseudallescheria boydii




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