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(Chest. 1999;116:1129-1131.)
© 1999 American College of Chest Physicians

Serial Scintigraphic Assessment of Iodine-123 Metaiodobenzylguanidine Lung Uptake in a Patient With High-Altitude Pulmonary Edema*

Tomonobu Koizumi, MD; Keishi Kubo, MD; Masayuki Hanaoka, MD; Hiroshi Yamamoto, MD; Shinji Yamaguchi, MD; Tadashige Fujii, MD and Toshio Kobayashi, MD

* From the First Department of Internal Medicine, Shinshu University School of Medicine, Asahi Matsumoto, Japan.

Correspondence to: Keishi Kubo, MD, First Department of Internal Medicine, Shinshu University School of Medicine, 3–1-1 Asahi Matsumoto, 390-8621, Japan; e-mail: keishik{at}gipac.shinshu-u.ac.jp

Iodine-123 metaiodobenzylguanidine (123I-MIBG) can be considered an indicator of pulmonary endothelial cell function. Serial 123I-MIBG images of the chest were acquired in a patient with high altitude pulmonary edema (HAPE). The initial evaluation was performed 7 days after admission. The lung to upper mediastinum ratios (LMRs) of 123I-MIBG uptake were 1.33 (for the right lung) and 1.12 (for the left lung). The second examination of 123I-MIBG lung uptake, which was performed 2 months later, showed LMRs of 1.39 (right lung) and 1.33 (left lung). We speculated that the decreased lung uptake of 123I-MIBG at the early recovery stage could reflect an impairment in pulmonary endothelial cell metabolic function in the development of HAPE.

Key Words: high-altitude pulmonary edema • hypoxia • iodine-123 metaiodobenzylguanidine • pulmonary endothelial cell function




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K.-H. Lee, B.-H. Ko, J.-Y. Paik, K.-H. Jung, J.-S. Bae, J.-Y. Choi, Y. S. Choe, and B.-T. Kim
Characteristics and Regulation of 123I-MIBG Transport in Cultured Pulmonary Endothelial Cells
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T. Arao, N. Takabatake, M. Sata, S. Abe, Y. Shibata, T. Honma, K. Takahashi, A. Okada, Y. Takeishi, and I. Kubota
In Vivo Evidence of Endothelial Injury in Chronic Obstructive Pulmonary Disease by Lung Scintigraphic Assessment of 123I-Metaiodobenzylguanidine
J. Nucl. Med., November 1, 2003; 44(11): 1747 - 1754.
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