| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
* From the Division of Pulmonary and Critical Care Medicine, Department of Medicine (Drs. Chang, Curtis, and Raghu), and the Department of Health Services (Drs. Curtis and Patrick), University of Washington, Seattle, WA.
Correspondence to: Ganesh Raghu, MD, FCCP, Division of Pulmonary and Critical Care Medicine, University of Washington, Box 356522, Seattle, WA 98195; e-mail: graghu{at}washington.edu
Study objectives: Health-related quality of life associated with interstitial lung disease has received little attention in clinical studies because there have been no validated methods for directly measuring it. We have assessed the validity of several generic and respiratory-specific quality-of-life instruments in patients with interstitial lung disease.
Design: Cross-sectional study.
Setting: Outpatient pulmonary clinic at a university referral center.
Patients: Fifty patients with interstitial disease such as idiopathic pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis, and asbestosis.
Interventions: Patients were administered four quality-of-life questionnaires, the Medical Outcomes Study Short Form 36 (SF-36), the Quality of Well-being scale (QWB), the Chronic Respiratory Questionnaire (CRQ), and the St. George’s Respiratory Questionnaire (SGRQ). Patients concomitantly underwent pulmonary function testing and performed a 6-min walk.
Measurements and results: Validation of these instruments was based on testing an a priori hypothesis that worse quality-of-life scores should correlate with more severe physiologic impairment demonstrated by pulmonary function tests, exercise tolerance on the 6-min walk, and dyspnea scores. Our patients, on average, had a moderate degree of physiologic impairment and demonstrated moderately decreased quality-of-life scores. Scores from all four quality-of-life questionnaires correlated significantly with 6-min walk distance and dyspnea score. Scores from the SF-36, QWB, and SGRQ showed significant correlation with FVC, FEV1, and diffusing capacity as well. The SF-36 and SGRQ consistently showed the strongest correlation with physical impairment.
Conclusions: Our findings indicate that preexisting quality-of-life instruments can be applied to patients with interstitial lung disease and suggest that the SF-36 and the SGRQ, in particular, are sensitive tools for assessing quality of life in these patients. Future intervention studies of patients with interstitial lung disease should consider using these measures.
Key Words: health status indicators • lung diseases • interstitial • pulmonary fibrosis • quality of life
This article has been cited by other articles:
|
|
 |
|
  N. M. Patel, D. J. Lederer, A. C. Borczuk, and S. M. Kawut Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis Chest, September 1, 2007; 132(3): 998 - 1006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Tansey, M. Louie, M. Loeb, W. L. Gold, M. P. Muller, J. de Jager, J. I. Cameron, G. Tomlinson, T. Mazzulli, S. L. Walmsley, et al. One-Year Outcomes and Health Care Utilization in Survivors of Severe Acute Respiratory Syndrome Arch Intern Med, June 25, 2007; 167(12): 1312 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Myint, R. N. Luben, P. G. Surtees, N. W. J. Wainwright, A. A. Welch, S. A. Bingham, N. J. Wareham, N. E. Day, and K-T. Khaw Respiratory function and self-reported functional health: EPIC-Norfolk population study Eur. Respir. J., September 1, 2005; 26(3): 494 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J Swigris, W G Kuschner, S S Jacobs, S R Wilson, and M K Gould Health-related quality of life in patients with idiopathic pulmonary fibrosis: a systematic review Thorax, July 1, 2005; 60(7): 588 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Azuma, T. Nukiwa, E. Tsuboi, M. Suga, S. Abe, K. Nakata, Y. Taguchi, S. Nagai, H. Itoh, M. Ohi, et al. Double-blind, Placebo-controlled Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., May 1, 2005; 171(9): 1040 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Swigris, M. K. Gould, and S. R. Wilson Health-Related Quality of Life Among Patients With Idiopathic Pulmonary Fibrosis Chest, January 1, 2005; 127(1): 284 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M A Spruit, M J Thomeer, R Gosselink, T Troosters, A Kasran, A J T Debrock, M G Demedts, and M Decramer Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status Thorax, January 1, 2005; 60(1): 32 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sarna, L. Evangelista, D. Tashkin, G. Padilla, C. Holmes, M. L. Brecht, and F. Grannis Impact of Respiratory Symptoms and Pulmonary Function on Quality of Life of Long-term Survivors of Non-Small Cell Lung Cancer Chest, February 1, 2004; 125(2): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. N. Lama, K. R. Flaherty, G. B. Toews, T. V. Colby, W. D. Travis, Q. Long, S. Murray, E. A. Kazerooni, B. H. Gross, J. P. Lynch III, et al. Prognostic Value of Desaturation during a 6-Minute Walk Test in Idiopathic Interstitial Pneumonia Am. J. Respir. Crit. Care Med., November 1, 2003; 168(9): 1084 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Cox, J. F. Donohue, C. D. Brown, Y. P. Kataria, and M. A. Judson The Sarcoidosis Health Questionnaire: A New Measure of Health-related Quality of Life Am. J. Respir. Crit. Care Med., August 1, 2003; 168(3): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Chan, M. M. Chan-Yeung, G. C. Ooi, C. L. Lam, T. F. Cheung, W. K. Lam, and K. W. Tsang Validation of the Hong Kong Chinese Version of the St. George Respiratory Questionnaire in Patients With Bronchiectasis Chest, December 1, 2002; 122(6): 2030 - 2037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Vassallo, J. H. Ryu, D. R. Schroeder, P. A. Decker, and A. H. Limper Clinical Outcomes of Pulmonary Langerhans'-Cell Histiocytosis in Adults N. Engl. J. Med., February 14, 2002; 346(7): 484 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Vries, B.L.J. Kessels, and M. Drent Quality of life of idiopathic pulmonary fibrosis patients Eur. Respir. J., May 1, 2001; 17(5): 954 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Randall Curtis and S. Borson Examining the Link between Sarcoidosis and Depression Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 306 - 308. [Full Text]
|
|
|
|
|
|
Jolanda De Vries, M. Drent, J. R. Curtis, D. L. Patrick, J. A. Chang, and G. Raghu Measuring Quality of Life in Interstitial Lung Disease Chest, July 1, 2000; 118(1): 275 - 275. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
