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(Chest. 1999;116:1434-1441.)
© 1999 American College of Chest Physicians

Nuclear Magnetic Resonance Spectroscopy*

Its Role in Providing Valuable Insight Into Diverse Clinical Problems

Kevin McCully, PhD; Donna Mancini and Sanford Levine, MD, FCCP

* From the Department of Exercise Science (Dr. McCully), Ramsey Student Center, University of Georgia, Athens, GA; the Department of Cardiology (Ms. Mancini), Columbia University, New York NY; and the Divison of Pulmonary Medicine (Mr. Levine), VA Medical Center, Philadelphia PA.

Correspondence to: Kevin McCully, PhD, Department of Exercise Science, Ramsey Student Center, University of Georgia, Athens, GA 30602-3654; e-mail: mccully{at}ibm.net

Abstract

Skeletal muscle plays an important role in respiratory and cardiovascular physiology. The ability to measure metabolic changes in skeletal muscle has been enhanced with the advent of magnetic resonance spectroscopy (MRS). MRS measurements have been used to understand the metabolic control of respiration and to evaluate metabolic changes in the muscle in patients with respiratory and cardiac diseases. The key to the respiratory control measurements is the ability to measure intracellular pH with MRS. Muscle oxidative metabolism has been measured in two ways: during steady-state exercise and using recovery kinetics. The similarities in the metabolic findings for pulmonary and coronary disease suggest the potential for some interesting common pathways.

Key Words: humans • magnetic resonance spectroscopy • metabolism • muscle • respiratory disease




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