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(Chest. 1999;116:1483-1485.)
© 1999 American College of Chest Physicians

Pulmonary Hypertension Caused by Graves’ Thyrotoxicosis*

Normal Pulmonary Hemodynamics Restored by 131I Treatment

Inaam A. Nakchbandi, MD; Joel A. Wirth, MD, FCCP and Silvio E. Inzucchi, MD

* From the Department of Medicine/Endocrinology, Yale University School of Medicine (Drs. Nakchbandi and Inzucchi), New Haven, CT, and the Maine Medical Center (Dr. Wirth), Portland, ME.

Correspondence to: Inaam A Nakchbandi, MD, Yale University School of Medicine, Department of Medicine/Endocrinology, PO Box 208020, New Haven, CT 06520-8020; e-mail: Endocrine.Fellows{at}Yale.edu

We describe a case of pulmonary hypertension, initially thought to be idiopathic, which resolved after treatment of Graves’ hyperthyroidism. Results of pulmonary artery catheterization before and after treatment are reported, and the effects of thyrotoxicosis on hemodynamics and pulmonary function are briefly reviewed. Possible mechanisms for development of pulmonary hypertension caused by hyperthyroidism include pulmonary vascular endothelial dysfunction or damage because of autoimmunity or the high cardiac output state, or increased metabolism of intrinsic pulmonary vasodilators.

Key Words: hyperthyroidism • pulmonary hypertension • thyroid disease




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