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(Chest. 1999;116:539S-545S.)
© 1999 American College of Chest Physicians

The Rationale and Use of Three-Dimensional Radiation Treatment Planning for Lung Cancer*

Lawrence B. Marks, MD and Gregory Sibley, MD

* From the Department of Radiation Oncology, Duke University Medical Center, Durham, NC.

Correspondence to: Lawrence B. Marks, MD, Box 3085, Duke University Medical Center, Durham, NC 27710; e-mail: marks{at}radonc.duke.edu

Treatment of lung cancer with conventional radiation therapy is associated with suboptimal local tumor control and poor long-term survival. Poor local tumor control may result from inaccurate tumor targeting, failure to satisfactorily conform to dose distribution with the target volume, and/or inadequate radiation doses. Three-dimensional treatment planning is a radiotherapy technique that provides more accurate dose targeting via the direct transfer of three-dimensional anatomic information from diagnostic scans into the planning process. This technology can assist treatment planning by providing dose-volume histograms, an estimation of normal tissue complication probabilities, and facilitate dose escalation. Preliminary clinical studies suggest that this is a feasible approach worthy of additional study. The three-dimensional tools provide new opportunities to better understand radiation-induced changes in pulmonary function.




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