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Endothelial Apoptosis^*

Could It Have a Role in the Pathogenesis and Treatment of Disease?

Tihomir tefanec, MD

^* From the Section of Critical Care Medicine, Saint Vincent Hospital and Medical Center, New York, NY.

Correspondence to: Tihomir tefanec, MD, Pulmonary Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021; e-mail: stefanet{at}mskcc.org

Endothelial apoptosis can be found in a number of diseases. This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.

Key Words: apoptosis • atherosclerosis • endothelium • heart failure • hypertension • primary pulmonary hypertension • sepsis

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