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(Chest. 2000;117:914-916.)
© 2000 American College of Chest Physicians

Treatment of Obstructive Airway Disease With a Cysteine Donor Protein Supplement*

A Case Report *

Bryce Lothian, MD; Vijaylaxmi Grey, PhD; R. John Kimoff, MD and Larry C. Lands, MD, PhD

* From the Department of Pediatrics (Drs. Lothian and Grey), Department of Biochemistry (Dr. Grey), and Division of Respiratory Medicine (Dr. Lands), McGill University Health Centre–Montreal Children’s Hospital, Montreal, Quebec, Canada; and Division of Respiratory Medicine (Dr. Kimoff), McGill University Health Centre–Royal Victoria Hospital, Montreal, Quebec, Canada.

Correspondence to: Larry C. Lands, MD, PhD, Assistant Director, Respiratory Medicine, The Montreal Children’s Hospital, Room D-380, 2300 Tupper St, Montreal, Quebec, Canada H3H 1P3; e-mail: larry.lands{at}muhc.mcgill.ca

Oxidant/antioxidant imbalance can occur in obstructive airways disease as a result of ongoing inflammation. Glutathione (GSH) plays a major role in pulmonary antioxidant protection. As an alternative or complement to anti-inflammatory therapy, augmenting antioxidant protection could diminish the effects of inflammation. We describe a case of a patient who had obstructive lung disease responsive to corticosteroids, and low whole blood GSH levels. After 1 month of supplementation with a whey-based oral supplement designed to provide GSH precursors, whole blood GSH levels and pulmonary function increased significantly and dramatically. The potential for such supplementation in pulmonary inflammatory conditions deserves further study.

Key Words: glutathione • inflammation • oxidative stress • supplementation






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