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(Chest. 2000;117:1195-1196.)
© 2000 American College of Chest Physicians

Hypercalcemia Due to Talc Granulomatosis*

Alexander Woywodt, MD; Wolfgang Schneider, MD; Ursula Goebel, MD and Friedrich C. Luft, MD

* From the Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, Berlin, Germany.

Correspondence to: Friedrich C. Luft, MD, Franz-Volhard-Clinic, Wiltbergstrasse 50, 13125 Berlin, Germany; e-mail: luft{at}fvk-berlin.de

Pulmonary disease due to talc, a group of hydrous magnesium silicates, is almost exclusively encountered after occupational exposure. One form of this rare disorder is talc granulomatosis. In varying degrees, hypercalcemia is typical of granulomatous disease but has not yet been reported in talcosis. We report the case of a former mold maker who presented with hypercalcemia. Laboratory findings indicated extra-renal 1-{alpha}-hydroxylation of 25-hydroxyvitamin D. Pulmonary infiltrates prompted a lung biopsy that disclosed talc granulomatosis. We suggest that talc granulomatosis should be added to the list of granulomatous disorders capable of causing hypercalcemia due to increased extra-renal 1-{alpha}-hydroxylation of 25-hydroxyvitamin D.

Key Words: granulomatous inflammation • hypercalcemia • talc • vitamin D




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