| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
* From the Departments of Clinical Chemistry (Drs. Lases, Gerritsen, and Haas) and Pulmonary Diseases (Drs. Duurkens), St. Antonius Hospital, Nieuwegein, The Netherlands.
Correspondence to: Vincent A.M. Duurkens, MD; Department of Pulmonary Diseases, St. Antonius Hospital, PO Box 2500, NL-3430 EM Nieuwegein, The Netherlands;
Study objectives: To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications.
Design: A prospective study.
Setting: A specialized thoracic surgical unit in a large referral hospital.
Patients: Twenty-eight patients with lung carcinoma undergoing thoracotomy.
Measurements: Exhaled H2O2 concentrations in breath condensate were measured by spectrophotometry, while malondialdehyde (MDA) levels in urine samples collected every 24 h were measured by reversed-phase, ion-pair high-performance liquid chromatography using ultraviolet detection.
Results: Our results show increased H2O2 and MDA levels in lobectomy patients compared with pneumonectomy patients. A strong correlation was found between the levels of H2O2 and MDA.
Conclusion: The present data support the hypothesis that oxidative stress may occur following pulmonary resection.
Key Words: hydrogen peroxide • lobectomy • malondialdehyde • oxidative stress • pneumonectomy • predictive value of tests • pulmonary edema
This article has been cited by other articles:
|
|
 |
|
  P. M. Heerdt, P. B. Lane, M. J. Crabtree, and B. J. Park Systemic oxidative stress associated with lung resection during single lung ventilation. Eur. J. Cardiothorac. Surg., September 1, 2006; 30(3): 568 - 569. [Full Text] [PDF]
|
|
|
|
 |
|
 W. Cao and Y. Duan Breath Analysis: Potential for Clinical Diagnosis and Exposure Assessment Clin. Chem., May 1, 2006; 52(5): 800 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Horvath, J. Hunt, P. J. Barnes, and On behalf of the ATS/ERS Task Force on Exhaled Bre Exhaled breath condensate: methodological recommendations and unresolved questions Eur. Respir. J., September 1, 2005; 26(3): 523 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Corradi, P. Pignatti, P. Manini, R. Andreoli, M. Goldoni, M. Poppa, G. Moscato, B. Balbi, and A. Mutti Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation Eur. Respir. J., December 1, 2004; 24(6): 1011 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Grichnik and T. A. D'Amico Acute Lung Injury and Acute Respiratory Distress Syndrome After Pulmonary Resection Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2004; 8(4): 317 - 334. [Abstract] [PDF]
|
|
|
|
 |
|
 P. D. Slinger Acute Lung Injury After Pulmonary Resection: More Pieces of the Puzzle Anesth. Analg., December 1, 2003; 97(6): 1555 - 1557. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Delogu, S. Moretti, G. Famularo, S. Marcellini, G. Santini, A. Antonucci, M. Marandola, and L. Signore Mitochondrial Perturbations and Oxidant Stress in Lymphocytes From Patients Undergoing Surgery and General Anesthesia Arch Surg, October 1, 2001; 136(10): 1190 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. MUTLU, K. W. GAREY, R. A. ROBBINS, L. H. DANZIGER, and I. RUBINSTEIN Collection and Analysis of Exhaled Breath Condensate in Humans Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 731 - 737. [Full Text] [PDF]
|
|
|
|
|
|
S. A. KHARITONOV and P. J. BARNES Exhaled Markers of Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 2001; 163(7): 1693 - 1722. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
