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B in Pulmonary Diseases*
* From the Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, and the Department of Veterans Affairs, Nashville, TN.
Correspondence to: John W. Christman, MD, FCCP, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T-1217 MCN, Nashville, TN 27232-2650; e-mail: john.christman{at}mcmail.vanderbilt.edu
Abstract
Nuclear factor-
B (NF-B) is a family of DNA-binding protein
factors that are required for transcription of most proinflammatory
molecules, including adhesion molecules, enzymes, cytokines, and
chemokines. NF-B activation seems to be a key early event in a
variety of cell and animal model systems developed to elucidate the
pathobiology of lung diseases. The purpose of this short review is to
describe what is known about the molecular biology of NF-B and to
review information that implicates NF-B in the pathogenesis of lung
disease, including ARDS, systemic inflammatory response syndrome,
asthma, respiratory viral infections, occupational and environmental
lung disease, and cystic fibrosis.
Key Words: air pollution • ARDS • asbestosis • asthma • ozone • respiratory syncytial virus • rhinovirus • sepsis • silicosis
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