HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Murciano, D. Articles by Milic-Emili, J. Search for Related Content PubMed PubMed Citation Articles by Murciano, D. Articles by Milic-Emili, J.

Flow Limitation and Dynamic Hyperinflation During Exercise in COPD Patients After Single Lung Transplantation^*

^* From the INSERM U408 (Drs. Murciano, Ferretti, Boczkowski, Sleiman, and Fournier), Service de Pneumologie, Hopital Beaujon, Clichy, France; and Meakins-Christie Laboratories (Dr. Milic-Emili), McGill University, Montreal, Canada.

Correspondence to: Daniele Murciano, MD, Service de Pneumologie, Hopital Beaujon, 100 boulevard du Général Leclerc, 92118 Clichy Cedex, France; e-mail: daniele.murciano{at}bjn.ap-hop-paris.fr

Study objective: Using the negative expiratory pressure (NEP) method, we have previously shown that patients receiving single lung transplantation (SLT) for COPD do not exhibit expiratory flow limitation and have little dyspnea at rest. In the present study, we assessed whether SLT patients exhibit flow limitation, overall hyperinflation, and dyspnea during exercise.

Methods: Expiratory flow limitation assessed by the NEP method and inspiratory capacity maneuvers used to determine end-expiratory lung volume (EELV) and end-inspiratory lung volume (EILV) were performed at rest and during symptom-limited incremental cycle exercise in eight SLT patients.

Results: At the time of the study, the mean (± SD) FEV₁, FVC, functional residual capacity, and total lung capacity (TLC) amounted to 55 ± 14%, 67 ± 12%, 137 ± 16%, and 110 ± 11% of predicted, respectively. At rest, all patients did not experience expiratory flow limitation and were without dyspnea. At peak exercise, the maximal mechanical power output and maximal oxygen consumption amounted to 72 ± 20% and 65 ± 8% of predicted, respectively, with a maximal dyspnea Borg score of 6 ± 3. All but one patient exhibited flow limitation and dynamic hyperinflation; the EELV and EILV amounted to 74 ± 5% and 95 ± 9% TLC, respectively. The patient who did not exhibit flow limitation during exercise had the lowest dyspnea score.

Conclusion: Most SLT patients for COPD exhibit expiratory flow limitation and dynamic hyperinflation during exercise, whereas maximal dyspnea is variable.

Key Words: exercise tolerance • expiratory flow limitation • hyperinflation

This article has been cited by other articles:

				P. M. A. Calverley and N. G. Koulouris Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology Eur. Respir. J., January 1, 2005; 25(1): 186 - 199. [Abstract] [Full Text] [PDF]

				A. Baydur, L. Wilkinson, R. Mehdian, B. Bains, and J. Milic-Emili Extrathoracic Expiratory Flow Limitation in Obesity and Obstructive and Restrictive Disorders: Effects of Increasing Negative Expiratory Pressure Chest, January 1, 2004; 125(1): 98 - 105. [Abstract] [Full Text] [PDF]

				F. Laghi and M. J. Tobin Disorders of the Respiratory Muscles Am. J. Respir. Crit. Care Med., July 1, 2003; 168(1): 10 - 48. [Abstract] [Full Text] [PDF]