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(Chest. 2000;118:1419-1423.)
© 2000 American College of Chest Physicians

Photodynamic Therapy*

A Case Series Demonstrating Its Role in Patients Receiving Mechanical Ventilation

Suketu K. Shah, MD and David Ost, MD, FCCP

* From the New York University School of Medicine, North Shore University Hospital, Manhasset, NY.

Correspondence to: David Ost, MD, FCCP, New York University School of Medicine, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030; e-mail: dost{at}nshs.edu

Photodynamic therapy (PDT) has long been used to treat cancers within the tracheobronchial tree. There have been many reports about the use of PDT for the treatment of carcinoma in situ and for obstructive endobronchial lesions. PDT has not been previously reported in patients receiving mechanical ventilation. PDT offers the advantages of a relatively short duration of treatment, a low side effect profile, and relatively low risk when compared to Nd-YAG laser in patients receiving mechanical ventilation. We report the first successful use of PDT to wean patients from mechanical ventilation.

Key Words: bronchoscopy • endobronchial disease • laser therapy • lung cancer • photodynamic therapy • respiratory failure




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