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From the Department of Health and Exercise Science (Drs. Foy, Rejeski, Berry, and Mr. Woodward), Wake Forest University, Winston-Salem, NC; and the Department of Biostatistics (Mr. Zaccaro), Wake Forest University Baptist Medical Center, Winston-Salem, NC.
Drs. Foy and Rejeski contributed equally to the
preparation of this article.
Correspondence to: W. Jack Rejeski, PhD, Department of Health and Exercise Science, PO Box 7868, Winston-Salem, NC 27109
Abstract
Study objectives: To determine whether long-term treatment with exercise therapy results in more favorable, disease-specific, health-related quality of life (HRQL) compared with short-term treatment with exercise therapy; and to determine whether there are gender differences in disease-specific HRQL among individuals randomized into the two treatment groups.
Design: Randomized clinical trial.
Setting: Center-based exercise therapy unit at a university.
Participants: One hundred forty patients with COPD; 118 completed trial.
Interventions: Short-term exercise therapy (3 months); long-term exercise therapy (18 months).
Measurements: Chronic Disease Respiratory Questionnaire (CRQ).
Results: After 3 months of treatment, there were significant improvements in all CRQ scores for men and women (p < 0.01), and for the total sample (p < 0.01). At 18 months, individuals randomized into the long-term group had significantly more favorable scores than the short-term group for dyspnea (p = 0.03), fatigue (p < 0.01), emotional function (p = 0.04), and mastery (p = 0.04). However, these effects were moderated by gender. That is, men in the long-term group reported significantly more favorable scores than men in the short-term group for dyspnea (0.04), fatigue (p < 0.001), emotional function (p = 0.02), and mastery (p = 0.02). At the 18-month assessment, there were no differences between long-term and short-term exercise therapy for women on any of the subscales of the CRQ.
Conclusions: Taken collectively, the CRQ data demonstrate that long-term exercise therapy has little added benefit for women over short-term exercise therapy; however, men derive significant benefits from extended training.
Key Words: pulmonary rehabilitation quality of life exercise training gender differences COPD
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