Chest ACCP Education Calendar
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mullins, C. D.
Right arrow Articles by Stoller, J. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mullins, C. D.
Right arrow Articles by Stoller, J. K.
(Chest. 2001;119:745-752.)
© 2001 American College of Chest Physicians

The Direct Medical Costs of {alpha}1-Antitrypsin Deficiency*

C. Daniel Mullins, PhD; Xingyue Huang, MS; Sanjay Merchant, MS, MBA; James K. Stoller, MD, FCCP and for the Alpha One Foundation Research Network Registry Investigators{dagger}

* From the University of Maryland School of Pharmacy (Dr. Mullins, Mr. Huang, and Mr. Merchant), Baltimore, MD; and Department of Pulmonary and Critical Care Medicine (Dr. Stoller), The Cleveland Clinic Foundation, Cleveland, OH. {dagger} A complete list of investigators is presented in the Appendix.

Correspondence to: C. Daniel Mullins, PhD, University of Maryland School of Pharmacy, 6th Floor, 100 N. Greene St, Baltimore, MD 21201; e-mail: dmullins{at}rx.umaryland.edu

Background: For individuals with emphysema because of severe {alpha}1-antitrypsin deficiency, specific therapy called IV augmentation therapy has been available since 1989. Such therapy consists of IV infusion of pooled human plasma {alpha}1-antiprotease.

Methods: To assess the direct medical costs of having {alpha}1-antitrypsin deficiency, the current study surveyed members of the Alpha One Foundation Registry for Individuals With {alpha}1-Antitrypsin Deficiency regarding their annual expenditures for treatment of this disease. Data regarding demographic features, {alpha}1-antitrypsin status, and health-resource utilization were collected from a self-administered questionnaire. Respondents were asked to provide total health-care expenditures, but costs by specific items of care (eg, drugs, physician visits, etc) were not available.

Results: Mean annual cost estimates were higher for PI*ZZ-phenotype individuals ($30,948, n = 292) than for non-PI*ZZ–phenotype individuals ($20,673, n = 53; p = 0.049). Among PI*ZZ-phenotype individuals, self-reported costs of health-care services were further analyzed for those 288 individuals whose {alpha}1-antiprotease use status was reported. For the 185 current {alpha}1-antiprotease users, the mean annual cost was $40,123 (median, $36,000).

Conclusions: Annual health-care expenditures by individuals with {alpha}1-antitrypsin deficiency are very high, whether or not they are currently receiving augmentation therapy. Augmentation therapy adds substantial costs, especially for heavier individuals who are receiving weekly infusions.

Key Words: {alpha}1-antitrypsin deficiency • cost • registry




This article has been cited by other articles:


Home page
 ChestHome page
D. K. Hogarth and G. Rachelefsky
Screening and Familial Testing of Patients for {alpha}1-Antitrypsin Deficiency
Chest, April 1, 2008; 133(4): 981 - 988.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J K Stoller and L S Aboussouan
{alpha}1-Antitrypsin deficiency {middle dot} 5: Intravenous augmentation therapy: current understanding
Thorax, August 1, 2004; 59(8): 708 - 712.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
American Thoracic Society/European Respiratory Society Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 818 - 900.
[Full Text] [PDF]

Home page
 ChestHome page
C. D. Mullins, J. Wang, and J. K. Stoller
Major Components of the Direct Medical Costs of {alpha}1-Antitrypsin Deficiency
Chest, September 1, 2003; 124(3): 826 - 831.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. R. Gildea, K. M. Shermock, M. E. Singer, and J. K. Stoller
Cost-Effectiveness Analysis of Augmentation Therapy for Severe {alpha}1-Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1387 - 1392.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. K. Stoller, R. Fallat, M. D. Schluchter, R. G. O'Brien, J. T. Connor, N. Gross, K. O'Neil, R. Sandhaus, and R. G. Crystal
Augmentation Therapy With {alpha}1-Antitrypsin: Patterns of Use and Adverse Events
Chest, May 1, 2003; 123(5): 1425 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. M. Tremblay, E. Vachon, C. Larouche, and Y. Bourbonnais
Inhibition of Human Neutrophil Elastase-Induced Acute Lung Injury in Hamsters by Recombinant Human Pre-elafin (Trappin-2)
Chest, February 1, 2002; 121(2): 582 - 588.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American College of Chest Physicians.