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(Chest. 2001;119:973-975.)
© 2001 American College of Chest Physicians

Pregnancy and Primary Pulmonary Hypertension*

Successful Outcome With Epoprostenol Therapy

Rosalyn Stewart, MD; Divina Tuazon, MD; Gayle Olson, MD and Alexander G. Duarte, MD

* From the Department of Internal Medicine (Drs. Stewart, Tuazon, and Duarte), Division of Pulmonary and Critical Care Medicine, and the Department of Obstetrics and Gynecology (Dr. Olson), University of Texas Medical Branch, Galveston, TX.

Correspondence to: Alexander G. Duarte, MD, Division of Pulmonary and Critical Care Medicine, John Sealy Annex, 301 University Blvd, Galveston, TX 77555-0561; e-mail: aduarte{at}utmb.edu

Primary pulmonary hypertension (PPH) associated with pregnancy carries a high maternal mortality rate. Short-term epoprostenol infusion has been demonstrated to improve the hemodynamic profile in patients with PPH. We report a successful maternal-fetal outcome with epoprostenol therapy during pregnancy, cesarean section, and postpartum in a patient with PPH. Epoprostenol therapy did not produce any physical or developmental abnormalities in the fetus. A favorable maternal-fetal outcome may occur with a multidisciplinary approach.

Key Words: cesarean section • epoprostenol • pulmonary hypertension • pregnancy




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