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(Chest. 2001;119:978-981.)
© 2001 American College of Chest Physicians

Recurrent Pulmonary Sarcoidosis in HIV-Infected Patients Receiving Highly Active Antiretroviral Therapy*

Roberta Lenner, MD; Zachary Bregman, MD; Alvin S. Teirstein, MD, FCCP and Louis DePalo, MD, FCCP

* From the Mount Sinai School of Medicine (Drs. Lenner, Teirstein, and DePalo), Mount Sinai-NYU Health; and Albert Einstein College of Medicine (Dr. Bregman), Beth Israel Medical Center, New York, NY.

Correspondence to: Roberta Lenner, MD, 515 E 72nd St, #10L, New York, NY 10021; e-mail: egandrobi{at}aol.com

HIV infection and sarcoidosis occur in the same age group, but there are only a few reports of the coexistence of the two disorders in the same individual. This infrequent occurrence has been attributed to the paucity of functioning CD4+ lymphocytes required for granuloma formation in patients with HIV infection. We report two patients with a history of remote sarcoidosis who later in life contracted HIV infection and developed recurrent, progressive pulmonary sarcoidosis while receiving highly active antiretroviral therapy (HAART). Progressive pulmonary sarcoidosis should be added to the differential diagnosis in patients receiving HAART for HIV infection who develop diffuse lung disease with recovery of CD4+ lymphocyte population.

Key Words: AIDS • HIV infection • immune reconstitution • pulmonary sarcoidosis




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