Chest ACCP Career Connection
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Guest Access | Sign In via User Name/Password
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Article Archive
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (55)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wijnhoven, H. A. H.
Right arrow Articles by de Haan, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wijnhoven, H. A. H.
Right arrow Articles by de Haan, M.
(Chest. 2001;119:1034-1042.)
© 2001 American College of Chest Physicians

Determinants of Different Dimensions of Disease Severity in Asthma and COPD*

Pulmonary Function and Health-Related Quality of Life

Hanneke A. H. Wijnhoven, MSc; Didi M. W. Kriegsman, MD, PhD; Arlette E. Hesselink, MSc; Brenda W. J. H. Penninx, PhD and Marten de Haan, MD, PhD

* From the Institute for Research in Extramural Medicine (EMGO Institute) (Mss. Wijnhoven and Hesselink, and Dr. Penninx), Vrije Universiteit; and the Department of General Practice (Drs. Kriegsman and de Haan), Vrije Universiteit, Amsterdam, The Netherlands.

Correspondence to: Hanneke A. H. Wijnhoven, MSc, Institute for Research in Extramural Medicine (EMGO Institute), Vrije Universiteit, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands; e-mail: HAH.Wijnhoven.emgo{at}med.vu.nl

Objective: To identify determinants of pulmonary function and health-related quality of life (HRQOL) to better understand disease severity in patients with asthma and COPD.

Design: Observational study.

Setting: Dutch general practice.

Patients: We studied 837 asthma patients and 231 COPD patients.

Results: The association between pulmonary function and HRQOL was poor for asthma (ß = 0.10) and COPD (ß = 0.19). Multivariately, in asthma, lower pulmonary function was associated with male gender, region of living, current smoking, use of inhaled short-acting bronchodilators, longer duration of disease, and higher diurnal variation in peak expiratory flow. In COPD, lower pulmonary function was associated with male gender, use of inhaled bronchodilators, more days and nights disturbed by respiratory complaints, not wheezing, and bronchial hyperresponsiveness. Reduced HRQOL was associated most strongly with more days and nights disturbed by respiratory complaints and dyspnea in both asthma and COPD. In asthma, additional associations were found with younger age, lower educational level, region of living, comorbidity, use of inhaled bronchodilators and corticosteroids, wheezing, chronic cough, sputum production, and bronchial hyperresponsiveness. In COPD, lower age, not smoking, chronic cough, and sputum production were associated with reduced HRQOL.

Conclusions: Pulmonary function and HRQOL appear to highlight different aspects of disease severity in asthma and COPD. Therefore, both measures should be taken into account in order to get a complete picture of severity of disease.

Key Words: asthma • COPD • determinants • disease severity • FEV1 • health-related quality of life • pulmonary function




This article has been cited by other articles:


Home page
 ChestHome page
M. J. Hegewald and R. O. Crapo
Socioeconomic Status and Lung Function
Chest, November 1, 2007; 132(5): 1608 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
N F Schlecht, K Schwartzman, and J Bourbeau
Dyspnea as clinical indicator in patients with chronic obstructive pulmonary disease
Chronic Respiratory Disease, October 1, 2005; 2(4): 183 - 191.
[Abstract] [PDF]

Home page
 ChestHome page
G. Xie, Y. Li, P. Shi, B. Zhou, P. Zhang, and Y. Wu
Baseline Pulmonary Function and Quality of Life 9 Years Later in a Middle-Aged Chinese Population
Chest, October 1, 2005; 128(4): 2448 - 2457.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Hoogendoorn, M. P. M. H. Rutten-van Molken, R. T. Hoogenveen, M. L. L. van Genugten, A. S. Buist, E. F. M. Wouters, and T. L. Feenstra
A dynamic population model of disease progression in COPD
Eur. Respir. J., August 1, 2005; 26(2): 223 - 233.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
L J Tata, J West, T Harrison, P Farrington, C Smith, and R Hubbard
Does influenza vaccination increase consultations, corticosteroid prescriptions, or exacerbations in subjects with asthma or chronic obstructive pulmonary disease?
Thorax, October 1, 2003; 58(10): 835 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Buhl, G. Hanf, M. Soler, G. Bensch, J. Wolfe, F. Everhard, K. Champain, H. Fox, and J. Thirlwell
The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma
Eur. Respir. J., November 1, 2002; 20(5): 1088 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
V. S. Fan, J. R. Curtis, S.-P. Tu, M. B. McDonell, and S. D. Fihn
Using Quality of Life to Predict Hospitalization and Mortality in Patients With Obstructive Lung Diseases*
Chest, August 1, 2002; 122(2): 429 - 436.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American College of Chest Physicians.