HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (25) Citing Articles via Google Scholar Google Scholar Articles by Garantziotis, S. Articles by Palmer, S. M. Search for Related Content PubMed PubMed Citation Articles by Garantziotis, S. Articles by Palmer, S. M.

Influenza Pneumonia in Lung Transplant Recipients^*

Clinical Features and Association With Bronchiolitis Obliterans Syndrome

^* From the Departments of Medicine, Division of Pulmonary and Critical Care Medicine (Drs. Garantziotis and Palmer), Pathology (Drs. Howell and Henshaw), Radiology (Dr. McAdams), and Surgery (Dr. Davis), Duke University Medical Center, Durham, NC.

Correspondence to: Scott M. Palmer, MD, MHS, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Box 3876, Bell Building, Duke University Medical Center, Durham, NC 27710; e-mail: palme002{at}mc.duke.edu

Influenza infection is increasingly recognized to cause significant morbidity and mortality in the community, especially in pediatric patients and elderly persons. Influenza infection, however, has not been well described among thoracic organ transplant recipients. We provide the first detailed clinical, radiographic, and histologic description of influenza pneumonia among three lung transplant recipients. The presentation varied considerably among the three patients and, in some cases, was atypical for influenza. Despite treatment, a persistent decline in pulmonary function occurred in all three patients after the acute illness. Interestingly, on follow-up biopsy specimens, each patient had histologic evidence of acute rejection and/or obliterative bronchiolitis. Additional research, therefore, is needed to clarify the relationship between influenza infection, acute rejection, and obliterative bronchiolitis.

Key Words: allograft rejection • bronchiolitis obliterans syndrome • influenza • lung transplantation • obliterative bronchiolitis

This article has been cited by other articles:

				A. P. Milstone, L. M. Brumble, J. Barnes, W. Estes, J. E. Loyd, R. N. Pierson III, and S. Dummer A single-season prospective study of respiratory viral infections in lung transplant recipients Eur. Respir. J., July 1, 2006; 28(1): 131 - 137. [Abstract] [Full Text] [PDF]

				M. G. Hartwig, J. Z. Appel, B. Li, C.-C. Hsieh, Y. H. Yoon, S. S. Lin, W. Irish, W. Parker, and R. D. Davis Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation J. Thorac. Cardiovasc. Surg., January 1, 2006; 131(1): 209 - 217. [Abstract] [Full Text] [PDF]

				J. Garbino, M. W. Gerbase, W. Wunderli, C. Deffernez, Y. Thomas, T. Rochat, B. Ninet, J. Schrenzel, S. Yerly, L. Perrin, et al. Lower Respiratory Viral Illnesses: Improved Diagnosis by Molecular Methods and Clinical Impact Am. J. Respir. Crit. Care Med., December 1, 2004; 170(11): 1197 - 1203. [Abstract] [Full Text] [PDF]

				A. P. Khalifah, R. R. Hachem, M. M. Chakinala, K. B. Schechtman, G. A. Patterson, D. P. Schuster, T. Mohanakumar, E. P. Trulock, and M. J. Walter Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 181 - 187. [Abstract] [Full Text] [PDF]

				R. M. Kotloff, V. N. Ahya, and S. W. Crawford Pulmonary Complications of Solid Organ and Hematopoietic Stem Cell Transplantation Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 22 - 48. [Abstract] [Full Text] [PDF]