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* From the Divisione di Pneumologia (Drs. Ferretti and Cavalli), Policlinico Sant’Orsola-Malpighi, Bologna, Italy; Divisione di Pneumologia (Dr. Giampiccolo), Ospedale di Castel San Pietro Terme, Imola, Italy; Meakins-Christie Laboratories (Dr. Milic-Emili), McGill University, Montreal, Quebec, Canada; and Clinica di Semeiotica Medica (Dr. Tantucci), Università di Ancona, Ancona, Italy.
Correspondence to: Claudio Tantucci, MD, Clinica di Semeiotica Medica, Università di Ancona, Ospedale Regionale Torrette, 60020 Ancona, Italy; e-mail: clatantu{at}tin.it
Background: Morbidly obese subjects, who often complain about breathlessness when lying down, breathe at low lung volume with a reduced expiratory reserve volume (ERV). Therefore, during tidal breathing the expiratory flow reserve is decreased, promoting expiratory flow limitation (EFL), which is more likely to occur in the supine position, when the relaxation volume of the respiratory system, and hence the functional residual capacity (FRC), decrease because of the gravitational effect of the abdominal contents.
Purpose: The aim of the study was to assess EFL and orthopnea in massively obese subjects and to evaluate whether orthopnea was associated with the development of supine EFL.
Methods: In 46 healthy obese subjects (18 men) with a mean (± SD) age of 44 ± 11 years and a mean body mass index (BMI) of 51 ± 9 kg/m2, we assessed EFL in both the seated and the supine positions by the negative expiratory pressure method and assessed postural changes in FRC by measuring the variations in the inspiratory capacity (IC) with recumbency. Simultaneously, dyspnea was evaluated in either position using the Borg scale dyspnea index (BSDI) to determine the presence of orthopnea, which was defined as any increase of the BSDI in the supine position.
Results: Partial EFL was detected in 22% and 59%, respectively, of the overall population in seated and supine position. The mean increase in the supine IC amounted to 120 ± 200 mL (4.1 ± 6.4%), indicating a limited decrease in FRC with recumbency in these subjects. Orthopnea, although mild (mean BSDI, 1.7 ± 1.3), was claimed by 20 subjects, and in 15 of them EFL occurred or worsened in the supine position. Orthopnea was associated with lower values of seated ERV (p < 0.05) and was marginally related to supine EFL values (p = 0.07). No significant effect of age, BMI, obstructive sleep apnea-hypopnea syndrome, FEV1, and forced expiratory flow at 75% of vital capacity was found on either orthopnea or EFL.
Conclusion: In morbidly obese subjects, EFL and dyspnea frequently occur with the subject in the supine position, and both supine EFL and low-seated ERV values are related to orthopnea, suggesting that dynamic pulmonary hyperinflation and intrinsic positive end-expiratory pressure may be partly responsible for orthopnea in massively obese subjects.
Key Words: body posture • flow limitation • lung function • negative expiratory pressure • orthopnea
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