| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
* From the Service de pneumologie et d’oncologie thoracique (Drs. Deygas, Froudarakis, and Vergnon), Hôpital Nord, Saint-Etienne; and Centre médico chirurgical du cèdre (Dr. Ozenne), Bois-Guillaume, France.
Correspondence to: Jean-Michel Vergnon, MD, PhD, Service de pneumologie et d’oncologie thoracique, Hôpital Nord, Avenue Albert Raimond, 42055 Saint-Etienne Cedex 2, France; e-mail: vergnon{at}univ-st-etienne.fr
Background: Treatment of early superficial bronchogenic carcinoma (ESBC) is under debate, and no consensus has been achieved. Different therapeutic methods have been proposed, including surgical resection and endoscopic methods.
Study objective: To assess the efficacy of cryotherapy in patients with ESBC.
Patients and methods: Patients included in the study had histologically proven ESBC after fiberoptic bronchoscopy. Cryotherapy was performed through a rigid bronchoscope. Efficacy was assessed by endoscopy with multiple biopsies 1 month after treatment and during the follow-up period. Parameters studied were response to treatment, adverse effects, and survival.
Results: We included 35 patients (34 men and 1 woman). The mean age was 61 ± 9 years. Multiple locations of ESBC were observed in seven patients (20%). Complete response rate at both 1 month and 1 year was 91% (32 patients). No severe adverse effects were noted. Local recurrence was observed within 4 years in 10 patients (28%). A follow-up period of at least 4 years was available in 22 patients; of them, 11 patients (50%) were long-term survivors.
Conclusion: Our results suggest that cryotherapy is an effective method of treatment in patients with ESBC. Due to its relative tolerance compared to surgery, cryotherapy could be proposed as a first-line therapy in this population with high carcinogenic risk.
Key Words: cryotherapy • curative intent • early superficial cancer • lung cancer • therapeutic endoscopy
This article has been cited by other articles:
|
|
 |
|
  L. Bertoletti, R. Elleuch, D. Kaczmarek, R. Jean-Francois, and J. M. Vergnon Bronchoscopic cryotherapy treatment of isolated endoluminal typical carcinoid tumor. Chest, November 1, 2006; 130(5): 1405 - 1411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J-M. Vergnon, R. M. Huber, and K. Moghissi Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur. Respir. J., July 1, 2006; 28(1): 200 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kawamura, Y. Izumi, N. Tsukada, K. Asakura, H. Sugiura, H. Yashiro, K. Nakano, S. Nakatsuka, S. Kuribayashi, and K. Kobayashi Percutaneous cryoablation of small pulmonary malignant tumors under computed tomographic guidance with local anesthesia for nonsurgical candidates J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1007 - 1013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, P. J. Littrup, Y. Duan, Y. Zhang, H. Feng, and Z. Nie Thoracic Masses Treated with Percutaneous Cryotherapy: Initial Experience with More than 200 Procedures Radiology, April 1, 2005; 235(1): 289 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Littrup, L. Freeman-Gibb, A. Andea, M. White, K. C. Amerikia, D. Bouwman, T. Harb, and W. Sakr Cryotherapy for Breast Fibroadenomas Radiology, January 1, 2005; 234(1): 63 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Moro-Sibilot, F. Fievet, M. Jeanmart, S. Lantuejoul, F. Arbib, M.H. Laverriere, E. Brambilla, and C. Brambilla Clinical prognostic indicators of high-grade pre-invasive bronchial lesions Eur. Respir. J., July 1, 2004; 24(1): 24 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. McWilliams, J. Mayo, S. MacDonald, J. C. leRiche, B. Palcic, E. Szabo, and S. Lam Lung Cancer Screening: A Different Paradigm Am. J. Respir. Crit. Care Med., November 15, 2003; 168(10): 1167 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Moro-Sibilot and C. Brambilla Photodynamic therapy: where do we go from here? Eur. Respir. J., September 1, 2003; 22(3): 399 - 400. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Jeanmart, S. Lantuejoul, F. Fievet, D. Moro, N. Sturm, C. Brambilla, and E. Brambilla Value of Immunohistochemical Markers in Preinvasive Bronchial Lesions in Risk Assessment of Lung Cancer Clin. Cancer Res., June 1, 2003; 9(6): 2195 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brambilla, F. Fievet, M. Jeanmart, F. de Fraipont, S. Lantuejoul, V. Frappat, G. Ferretti, P.Y. Brichon, and D. Moro-Sibilot Early detection of lung cancer: role of biomarkers Eur. Respir. J., January 1, 2003; 21(39_suppl): 36S - 44s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Mathur, E. Edell, T. Sutedja, and J.-M. Vergnon Treatment of Early Stage Non-small Cell Lung Cancer Chest, January 1, 2003; 123(1_suppl): 176S - 180S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Banerjee, P. H. Rabbitts, P. J. M. George, L. Thiberville, S. Bota, J.-B. Auliac, C. Paris, J. Metayer, G. Nouvet, and R. Sesboue Are all high-grade preinvasive lesions premalignant, and should they all be treated? Am. J. Respir. Crit. Care Med., May 15, 2002; 165(10): 1452 - 1453. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
