HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Medinger, A. E. Articles by Rohatgi, P. K. Search for Related Content PubMed PubMed Citation Articles by Medinger, A. E. Articles by Rohatgi, P. K.

Sarcoidosis^*

The Value of Exercise Testing

^* From the Pulmonary Physiology Laboratory, Veterans Affairs Medical Center; and Department of Medicine, George Washington University, Washington, DC.

Correspondence to: Ann E. Medinger MD, FCCP, 5605 Park St, Chevy Chase, MD 20815

Study objectives: To evaluate exercise testing for the assessment of the extent of pulmonary disease in patients with sarcoidosis.

Design: Retrospective analysis of consecutive patients with sarcoidosis referred to the Pulmonary Physiology Laboratory between 1992 and 1997, who completed at least 6 min of progressive bicycle exercise. Resting and exercise pulmonary function measurements were compared to radiographic stage of disease.

Setting: Pulmonary Physiology Laboratory at Washington, DC, Veterans Affairs Medical Center.

Patients: Forty-eight outpatient veterans with biopsy specimen-proven sarcoidosis.

Results: Across all radiographic stages of sarcoidosis, total lung capacity, resting diffusing capacity, and exercise gas exchange measurements had a significant variance with radiographic stage. Across the early radiographic stage disease (stages 0 to 2), the change in alveolar-arterial oxygen pressure gradient between rest and exercise, normalized for oxygen uptake, was the most significant measurement in its variation with radiographic stage.

Conclusions: Changes in gas exchange with exercise may be the most sensitive physiologic measurements to assess the extent of disease in early radiographic stages of sarcoidosis.

Key Words: clinical exercise testing • extent of disease • pulmonary function testing • radiographic stage • sarcoidosis

This article has been cited by other articles:

				R. P. Baughman, B. K. Sparkman, and E. E. Lower Six-Minute Walk Test and Health Status Assessment in Sarcoidosis Chest, July 1, 2007; 132(1): 207 - 213. [Abstract] [Full Text] [PDF]

				M A Spruit, M J Thomeer, R Gosselink, T Troosters, A Kasran, A J T Debrock, M G Demedts, and M Decramer Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status Thorax, January 1, 2005; 60(1): 32 - 38. [Abstract] [Full Text] [PDF]

				A. Sette, J. A. Neder, L. E. Nery, J. Kavakama, R. T. Rodrigues, M. Terra-Filho, S. Guimaraes, E. Bagatin, and N. Muller Thin-Section CT Abnormalities and Pulmonary Gas Exchange Impairment in Workers Exposed to Asbestos Radiology, July 1, 2004; 232(1): 66 - 74. [Abstract] [Full Text] [PDF]

				C. Lamberto, H. Nunes, P. Le Toumelin, F. Duperron, D. Valeyre, and C. Clerici Membrane and Capillary Blood Components of Diffusion Capacity of the Lung for Carbon Monoxide in Pulmonary Sarcoidosis: Relation to Exercise Gas Exchange Chest, June 1, 2004; 125(6): 2061 - 2068. [Abstract] [Full Text] [PDF]

				X.-G. Sun, J. E. Hansen, N. Garatachea, T. W. Storer, and K. Wasserman Ventilatory Efficiency during Exercise in Healthy Subjects Am. J. Respir. Crit. Care Med., December 1, 2002; 166(11): 1443 - 1448. [Abstract] [Full Text] [PDF]

				J. E. Hansen, A. E. Medinger, S. Khouri, and P. K. Rohatgi Sarcoidosis and Gas Exchange Measures Chest, March 1, 2002; 121(3): 1004 - 1005. [Full Text] [PDF]