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(Chest. 2001;120:634-648.)
© 2001 American College of Chest Physicians

Mitochondrial Disease*

A Pulmonary and Critical-Care Medicine Perspective

Alison S. Clay, MD; Mehrdad Behnia, MD and Kevin K. Brown, MD, FCCP

* From the Department of Internal Medicine (Dr. Clay), Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine (Dr. Behnia), Indiana University School of Medicine, Indianapolis, IN; and the Department of Pulmonary Sciences and Critical Care Medicine (Dr. Brown), University of Colorado Health Sciences Center, Denver, CO.

Correspondence to: Kevin K. Brown, MD, FCCP, Director, Clinical Interstitial Lung Disease Program, National Jewish Medical and Research Center, 1400 Jackson St, F108, Denver, CO 80222; e-mail: brownk{at}njc.org

The clinical spectrum of mitochondrial diseases has expanded dramatically in the last decade. Abnormalities of mitochondrial function are now thought to participate in a number of common adult diseases, ranging from exercise intolerance to aging. This review outlines the common presentations of mitochondrial disease in ICUs and in the outpatient setting and discusses current diagnostic and therapeutic options as they pertain to the pulmonary and critical-care physician.

Key Words: critical care • exercise intolerance • exercise testing • hypoventilation • lactic acidosis • mitochondria • mitochondrial genome • mitochondrial myopathy • muscle biopsy • muscle weakness




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