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(Chest. 2002;121:292-295.)
© 2002 American College of Chest Physicians

Human Recombinant Activated Protein C in Meningococcal Sepsis*

Gregory Wcisel, MD; David Joyce, MD; Arna Gudmundsdottir, MD and D. Michael Shasby, MD, FCCP

* From the Department of Medicine, University of Iowa College of Medicine, Iowa City, IA.

Correspondence to: D. Michael Shasby, MD, FCCP, Department of Medicine, University of Iowa College of Medicine, Iowa City, IA 52242; e-mail: shasby{at}blue.weeg.uiowa.edu

A 19-year-old woman presented with purpura fulminans and septic shock; subsequently, progressive coagulopathy, widespread purpura fulminans associated with meningococcemia, severe shock, respiratory, and renal failure developed. This clinical course was associated with depletion of functional protein C levels to < 5%. We describe her clinical course and therapy with human recombinant activated protein C. (CHEST 2002; 121:292–295)

Key Words: human recombinant activated protein C • purpura fulminans • renal failure • respiratory failure • septic shock






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