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(Chest. 2002;121:188S-191S.)
© 2002 American College of Chest Physicians

A Model of Tobacco Smoke-Induced Airflow Obstruction in the Guinea Pig*

Joanne L. Wright, MD and Andrew Churg, MD

* From the Department of Pathology, University of British Columbia, Vancouver, BC, Canada.

Correspondence to: Joanne L. Wright, MD, Department of Pathology, University of British Columbia, 2211 Westbrook Mall, Vancouver, BC, V6T 2B5 Canada; e-mail: jlwright{at}interchange.ubc.ca

Animal models have proven to be extremely worthwhile in the investigations of cigarette smokeinduced lung disease. We have found the guinea pig to be useful, with a large number of advantages and few disadvantages when used in our experimental circumstances. Other animal models exist, however, and the investigator should select the model that is most suited to the hypothesis to be tested.

Key Words: animal models • cigarette smoke • COPD • emphysema • guinea pig • pulmonary hypertension • species differences




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