| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Guest Access | Sign In via User Name/Password
|
|
|
|||||||
Guest Access | Sign In via User Name/Password |
|||||||||
* From the Service de Pneumologie et d’Allergologie Pédiatriques (Drs. Le Bourgeois, Goncalves, Le Clainche, Benoist, Scheinmann, and de Blic) and Laboratoire d’Anatomopathologie (Dr. Fournet), Hôpital Necker-Enfants Malades, Paris, France.
Correspondence to: Muriel Le Bourgeois, MD, Service de Pneumologie et d’Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France; e-mail: muriel.lebourgeois{at}nck.ap-hop-paris.fr
Study objective: To determine the cell profile of BAL from infants with severe recurrent wheezing who were not acutely ill at the time of investigation, suggesting an ongoing inflammation.
Design and patients: In a retrospective study, we determined BAL cell profiles for 83 children with wheezing aged 4 to 32 months (mean ± SD, 11.3 ± 5.5 months). Fiberoptic bronchoscopy was performed in children with severe recurrent wheezy bronchitis unresponsive to inhaled steroids. These children were compared with 17 children aged 6 to 36 months (mean, 15.1 ± 7.5 months) with various nonwheezing pulmonary diseases. Children were included as control subjects if they had no endobronchial inflammation and no atopy.
Results: The BAL cell profile of young children with wheezing typically includes a significantly higher cell count (mean, 644.4 ± 956.8 x 103/mL vs 313 ± 203.2 x 103/mL, p = 0.008), a significantly higher percentage of neutrophils (mean, 9 ± 12.1% vs 2.1 ± 2.2%, p = 0.003), and a higher neutrophil count (mean, 43.2 ± 81.6 x 103/mL vs 7.9 ± 11.8 x 103/mL, p = 0.003), as compared with control subjects. The larger number of neutrophils in children with wheezing was not correlated with bacterial or viral infection, or with age, sex, or atopic status. In contrast to the situation in asthmatic adults, eosinophil levels were not higher in children with wheezing than in control subjects (mean, 0.09 ± 0.27% vs 0.08 ± 0.25%).
Conclusion: Neutrophil-mediated inflammation in the airways appears to better characterize severe recurrent wheezing in children < 3 years old.
Key Words: asthma • BAL • flexible bronchoscopy • infants • wheezing
This article has been cited by other articles:
|
|
 |
|
  C M McDougall and P J Helms Neutrophil airway inflammation in childhood asthma. Thorax, September 1, 2006; 61(9): 739 - 741. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Bisgaard, M. N. Hermansen, L. Loland, L. B. Halkjaer, and F. Buchvald Intermittent inhaled corticosteroids in infants with episodic wheezing. N. Engl. J. Med., May 11, 2006; 354(19): 1998 - 2005. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Diagnosis of asthma Can. Med. Assoc. J., September 13, 2005; 173(6_suppl): S15 - S19. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saglani, K. Malmstrom, A. S. Pelkonen, L. P. Malmberg, H. Lindahl, M. Kajosaari, M. Turpeinen, A. V. Rogers, D. N. Payne, A. Bush, et al. Airway Remodeling and Inflammation in Symptomatic Infants with Reversible Airflow Obstruction Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Archer, J. L. H. Cramton, J. C. Pfau, G. Colasurdo, and A. Holian Airway responsiveness after acute exposure to urban particulate matter 1648 in a DO11.10 murine model Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L337 - L343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rojas-Ramos, A.F. Avalos, L. Perez-Fernandez, F. Cuevas-Schacht, E. Valencia-Maqueda, and L.M. Teran Role of the chemokines RANTES, monocyte chemotactic proteins-3 and -4, and eotaxins-1 and -2 in childhood asthma Eur. Respir. J., August 1, 2003; 22(2): 310 - 316. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
