HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Koike, A. Articles by Itoh, H. Search for Related Content PubMed PubMed Citation Articles by Koike, A. Articles by Itoh, H.

Relation Between Oscillatory Ventilation at Rest Before Cardiopulmonary Exercise Testing and Prognosis in Patients With Left Ventricular Dysfunction^*

^* From The Cardiovascular Institute (Drs. Koike, Aizawa, Fu, Watanabe, and Itoh, and Mr. Tajima), Tokyo; and Toride Kyodo General Hospital (Dr. Shimizu), Ibaraki, Japan.

Correspondence to: Akira Koike, MD, The Cardiovascular Institute, 3-10, Roppongi 7-chome, Minato-ku, Tokyo 106-0032, Japan; e-mail: koike{at}cepp.ne.jp

Background: Although nocturnal Cheyne-Stokes respiration alternating between hyperpnea and hypopnea has been considered a sign of severe heart failure, the clinical status of cardiac patients who exhibit oscillatory ventilation during wakefulness has not been clarified. This study was carried out to determine the relation between oscillatory ventilation during wakefulness and exercise capacity in patients with chronic heart disease. We also evaluated retrospectively whether the presence of oscillatory ventilation influences the long-term prognosis in these patients.

Methods: A total of 164 patients with left ventricular dysfunction performed a symptom-limited incremental exercise test. Respiratory gas exchange was measured on a breath-by-breath basis throughout the test. Oscillatory ventilation was defined when clear ventilatory oscillation of at least two consecutive cycles was identified at rest before exercise testing and the difference between the peak and nadir of oscillating ventilation was > 30% of the mean value of ventilation.

Results: Oscillatory ventilation was noted in 45 of 164 cardiac patients (27%), and the magnitude (mean ± SD) of oscillation in these patients was 45.5 ± 16.9%. Patients with oscillatory ventilation had significantly lower left ventricular ejection fraction than those without it (40.7 ± 12.7% vs 44.9 ± 11.6%, p < 0.05). However, parameters of exercise capacity such as the peak oxygen uptake (O₂), the slope of the increase in O₂ relative to the increase in work rate (O₂/WR), and the ratio of the increase in ventilation to the increase in carbon dioxide output (E/CO₂) were not significantly different between the two groups. The mortality rate during 1,797 ± 599 days of follow-up did not differ between the groups (p = 0.65).

Conclusions: Oscillatory ventilation present at rest before cardiopulmonary exercise testing is not significantly related to the peak O₂, O₂/WR, E/CO₂, or prognosis in patients with left ventricular dysfunction.

Key Words: cardiac patient • exercise capacity • oscillatory ventilation • prognosis

This article has been cited by other articles:

				N. M. Heller, S. Matsukura, S. N. Georas, M. R. Boothby, P. B. Rothman, C. Stellato, and R. P. Schleimer Interferon-{gamma} Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol., November 1, 2004; 31(5): 573 - 582. [Abstract] [Full Text] [PDF]