HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Guest Access | Sign In via User Name/Password

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to My Personal Article Archive Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (25) Citing Articles via Google Scholar Google Scholar Articles by Neff, T. A. Articles by Russi, E. W. Search for Related Content PubMed PubMed Citation Articles by Neff, T. A. Articles by Russi, E. W.

Long-term Assessment of Lung Function in Survivors of Severe ARDS^*

^* From the Institute of Anesthesiology (Drs. Neff and Stein), University Hospital Zurich; Department of Surgery (Dr. Stocker), Division of Trauma Surgery, University Hospital Zurich; Department of Internal Medicine (Dr. Frey), Regional Hospital Sursee; and Department of Internal Medicine (Dr. Russi), Pulmonary Division, University Hospital Zurich, Switzerland.

Correspondence to: Erich W. Russi, MD, FCCP, Department of Internal Medicine, Pulmonary Division, University Hospital Zurich, Raemistrasse 100 CH-8091, Zurich, Switzerland; e-mail: erich.russi{at}dim.usz.ch

Study objectives: To investigate the long-term outcome of lung function in survivors of severe ARDS after modern treatment strategies including lung protective mechanical ventilation and prone positioning maneuvers.

Design: Follow-up cohort study.

Setting: University hospital pulmonary division and level 1 trauma center.

Patients: Sixteen survivors of severe ARDS (from 1992 to 1994) with a lung injury score 2.5.

Measurements: The follow-up study (from 1995 to 1996) included interview, physical examination, chest radiographs, static and dynamic lung volumes, diffusion capacity of the lung for carbon monoxide (DLCO), blood gas analysis, and cardiopulmonary exercise testing (CPET).

Results: The mean ± SD interval between hospital discharge and functional assessment was 29.5 ± 8.7 months (range, 15.0 to 40.7 months). In approximately one half of the patients, mild abnormalities in static and dynamic lung volumes were found. In 25% (4 of 16 patients), lung function was obstructive; in 25% (4 of 16 patients), lung function was restrictive; and in 6.3% (1 of 16 patients), a combined obstructive-restrictive pattern was revealed. DLCO was impaired in 12.5% (2 of 16 patients); gas exchange during exercise was impaired in 45.5% (5 of 11 patients).

Conclusions: Residual obstructive and restrictive defects as well as impaired pulmonary gas exchange remain common after severe ARDS. CPET is a very sensitive measure to evaluate residual impairment of lung function after ARDS. Using CPET, reduced pulmonary gas exchange can be detected in many patients with normal DLCO.

Key Words: ARDS • exercise test • follow-up studies • lung function tests • outcome assessment

This article has been cited by other articles:

				N. F. Voelkel, I. S. Douglas, and M. Nicolls Angiogenesis in Chronic Lung Disease Chest, March 1, 2007; 131(3): 874 - 879. [Abstract] [Full Text] [PDF]

				I. S. Douglas, F. D. del Valle, R. A. Winn, and N. F. Voelkel beta-Catenin in the Fibroproliferative Response to Acute Lung Injury Am. J. Respir. Cell Mol. Biol., March 1, 2006; 34(3): 274 - 285. [Abstract] [Full Text] [PDF]

				D. S. Hui, K. T. Wong, F. W. Ko, L. S. Tam, D. P. Chan, J. Woo, and J. J.Y. Sung The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors Chest, October 1, 2005; 128(4): 2247 - 2261. [Abstract] [Full Text] [PDF]

				K.-C. Ong, A. W.-K. Ng, L. S.-U Lee, G. Kaw, S.-K. Kwek, M. K.-S. Leow, and A. Earnest 1-Year Pulmonary Function and Health Status in Survivors of Severe Acute Respiratory Syndrome Chest, September 1, 2005; 128(3): 1393 - 1400. [Abstract] [Full Text] [PDF]

				J C K Chan Recovery pathway of post-SARS patients Thorax, May 1, 2005; 60(5): 361 - 362. [Full Text] [PDF]

				D S Hui, G M Joynt, K T Wong, C D Gomersall, T S Li, G Antonio, F W Ko, M C Chan, D P Chan, M W Tong, et al. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors Thorax, May 1, 2005; 60(5): 401 - 409. [Abstract] [Full Text] [PDF]

				C K Ng, J W M Chan, T L Kwan, T S To, Y H Chan, F Y Y Ng, and T Y W Mok Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors Thorax, October 1, 2004; 59(10): 889 - 891. [Abstract] [Full Text] [PDF]

				K-C. Ong, A.W-K. Ng, L.S-U. Lee, G. Kaw, S-K. Kwek, M.K-S. Leow, and A. Earnest Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome Eur. Respir. J., September 1, 2004; 24(3): 436 - 442. [Abstract] [Full Text] [PDF]

				H.-H. Hsu, C. Tzao, C.-P. Wu, W.-C. Chang, C.-L. Tsai, H.-J. Tung, and C.-Y. Chen Correlation of High-Resolution CT, Symptoms, and Pulmonary Function in Patients During Recovery From Severe Acute Respiratory Syndrome Chest, July 1, 2004; 126(1): 149 - 158. [Abstract] [Full Text] [PDF]