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Statins, Inflammation, and Sepsis^*

Hypothesis

^* From the Medical Intensive Care Unit, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel.

Correspondence to: Yaniv Almog, MD, Medical Intensive Care Unit, Soroka University Medical Center, PO Box 151, Beer-Sheva, 84101 Israel; e-mail: almogya{at}bgumail.bgu.ac.il

Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against sepsis by virtue of diverse anti-inflammatory effects that are independent of their lipid-lowering ability.

Key Words: anti-inflammatory • apoptosis • nitric oxide • sepsis • statins

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