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Thrombin, Inflammation, and Cardiovascular Disease^*

An Epidemiologic Perspective

^* From the Laboratory for Clinical Biochemistry Research, College of Medicine, University of Vermont, Colchester, VT.

Correspondence to: Russell P. Tracy, PhD, Director, Laboratory for Clinical Biochemistry Research, University of Vermont, 208 South Park Dr, Suite 2, Colchester, VT 05446; e-mail: russell.tracy{at}uvm.edu

The exploration of coagulation led to identifying inflammation as a major factor in arterial disease throughout life. "Integrative molecular physiology" reflects our emerging understanding of how coagulation and inflammation integrate with one another, in both normal physiology and in pathophysiology. Our own responses to environmental challenge provide much of the damage that cumulatively results in chronic cardiovascular disease. Only by intervening in exquisitely precise ways can we hope to effectively and safely modify the course of lifelong chronic diseases, such as atherosclerosis.

Key Words: cardiovascular disease risk • coagulation • epidemiology • fibrinolysis • inflammation • thrombosis

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