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Brain Natriuretic Peptide in the Management of Heart Failure^*

The Versatile Neurohormone

Simon de Denus, MSc(Pharm); Chantal Pharand, PharmD and David R. Williamson, MSc(Pharm)

^* From the Philadelphia College of Pharmacy (Mr. de Denus), University of Sciences of Philadelphia, Philadelphia, PA; and Faculty of Pharmacy (Dr. Pharand and Mr. Williamson), Université de Montréal and Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada. As part of his fellowship training, Mr. de Denus has served as a coinvestigator in Acute Decompensated Heart Failure Registry (ADHERE), which was sponsored by Scios, the manufacturer of Natrecor.

Correspondence to: David R. Williamson, MSc(Pharm), Assistant Professor, Faculté de Pharmacie, Université de Montréal, Hôpital du Sacré-Coeur de Montréal, 5400 Blvd Gouin Ouest, Montréal, QC, H4J 1C5 Canada; e-mail: david.williamson{at}umontreal.ca

Brain natriuretic peptide (BNP), also called B-type natriuretic peptide, is a member of a family of structurally related hormones, the natriuretic peptides. Current data suggest that measurement of BNP plasma concentrations is a useful tool in the diagnosis of acute heart failure in patients presenting to an emergency department with acute dyspnea. Furthermore, BNP constitutes a promising new marker of prognosis after an acute coronary syndrome episode and in patients with chronic heart failure. Nesiritide, the human recombinant form of BNP, is a new vasodilator used in the treatment of acute heart failure that has several potential advantages over current drug therapy.

Key Words: brain natriuretic peptide • congestive heart failure • nesiritide

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